Dilated cardiomyopathy due to iron overload (Q98625)

Dilated cardiomyopathy due to iron overload occurs either primarily due to a genetic predisposition to absorb and store iron in excess amounts (hereditary haemochromatosis), or secondarily as a complication of other haematologic disorders that require chronic transfusion therapy (such as sickle cell disease and thalassaemia), repeated injections of parenteral iron (such as for chronic kidney disease), or due to excessive iron ingestion. Additional information: Iron-overload cardiomyopathy in children and young adults with the above conditions begins as a restrictive cardiomyopathy with severe diastolic dysfunction, eventually progressing to end-stage dilated cardiomyopathy with mixed systolic and diastolic dysfunction.