X-linked spastic paraplegia type 2 (Q97741)

Spastic paraplegia type 2 (SPG2) is an X-linked leukodystrophy characterised primarily by spastic gait and autonomic dysfunction. When additional central nervous system (CNS) signs, such as intellectual deficit, ataxia, or extrapyramidal signs, are present, the syndrome is referred to as complicated SPG2.