Malignant pachymeningitis (Q90286)

Inflammation of the pachymeninges resulting in localised or diffuse thickening of the dura mater caused by carcinomatous, leukaemic or lymphomatous infiltration. The cranial and/or the spinal dura may be affected. Neurological features includes headache, visual disturbance, cranial nerve palsies, ataxia and with spinal involvement, limb weakness, sensory impairment and sphincter disturbances . Diagnosis may be aided by neuroimaging, spinal fluid analysis and dural biopsy.