Primary cutaneous CD4-positive small or intermediate pleomorphic T-cell lymphoproliferative disorder (Q89594)

This reactive lymphoproliferative disorder usually presents with a solitary plaque or tumour on the face, neck, or upper trunk. Morphologically, it is composed of small to medium-sized CD4-positive, CD8-negative, and CD30-negative pleomorphic T-lymphocytes. A small number of large pleomorphic T-lymphocytes may also be present. The lymphocytic infiltrate is dermal. Focal epidermotropism and subcutaneous involvement may be present. It has a favourable prognosis.