Monomelic amyotrophy of lower limb (Q83617)

Monomelic amyotrophy of the lower limbs is relatively rare. It is characterised by insidious onset of lower limb weakness and wasting, predominantly affecting the posterior calf and anterior thigh muscles. Like monomelic amyotrophy of the upper limb, it most frequently affects males, but unlike the upper limb variant, age of onset is typically older. Slow progression followed by stabilisation is the usual clinical course.