Naegeli-Franceschetti-Jadassohn syndrome (Q83104)

Naegeli-Franceschetti-Jadassohn syndrome is a rare ectodermal dysplasia that affects the skin, sweat glands, nails, and teeth. The cardinal features are absence of dermatoglyphics (fingerprints), reticular cutaneous hyperpigmentation (starting at about the age of 2 years without a preceding inflammatory stage), hypohidrosis with diminished sweat gland function and discomfort provoked by heat, nail dystrophy, tooth enamel defects, and moderate hyperkeratosis of the palms and soles.