Severe dengue (Q38252)

Clinical signs include: 1. Severe plasma leakage leading to shock (dengue shock syndrome - DSS) and/or fluid accumulation with respiratory distress; 2. severe bleeding as evaluated by clinician, 3. severe organ involvement: Liver AST or ALT ≥ 1000, CNS: impaired consciousness, involvement of other organs, as myocarditis or nephritis.