Steroid sensitive nephrotic syndrome (Q92371)

Acute nephrotic syndrome which resolves within 4-6 weeks on treatment with prednisolone or prednisone 1mg/kg/day, maximum 80mg for (adults), 60mg/m²/day (children).This response usually indicates minimal change glomerulonephritis as the likely histological diagnosis. Of children with nephrotic syndrome 80% are steroid responsive, renal biopsy is not usually performed and thus the diagnosis is based on response to therapy, supported by the presence of selective proteinuria. The same approach in adults is not usual without renal biopsy due to the lower frequency of remission and the lack of reliability of selective proteinuria as a diagnostic tool, but is useful in relapsing nephrotic syndrome previously shown to be previously steroid responsive as might occur after childhood nephrotic syndrome.