Hypereosinophilic syndrome (Q101690)

Hypereosinophilic syndrome (HES) constitute a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia (greater than 1.5 x 10[9th power]/L for more than six consecutive months, associated with evidence of eosinophil-induced organ damage, where other causes of hypereosinophilia such as allergic, parasitic, and malignant disorders have been excluded. Additional information: Clinical presentations vary, from benign cutaneous involvement to severe manifestations such as endomyocardial fibrosis and thromboembolism. Subtypes include the association with Churg-Strauss syndrome (eosinophilic granulomatosis with polyangiitis), myeloid neoplasms, T cell lymphocytic variant and Loeffler's endocarditis, as well as idiopathic.