Primary systemic amyloidosis affecting skin or oral cavity (Q96378)
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Primary systemic amyloid, due to abnormal secretion of immunoglobulin light chain fragments as a result of plasma cell dyscrasia or multiple myeloma, may present in the skin. The commonest findings are spontaneous petechial haemorrhages, purpura and bruising. Such haemorrhage has a predilection for skin with clinically apparent amyloid infiltration: smooth, shiny, waxy, translucent papules and plaques develop, particularly on the eyelids, the neck and in flexural areas. Macroglossia occurs in 10 per cent of cases.
| Language | Label | Description | Also known as |
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| default for all languages | ID_848611604 |
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| English | Primary systemic amyloidosis affecting skin or oral cavity |
Primary systemic amyloid, due to abnormal secretion of immunoglobulin light chain fragments as a result of plasma cell dyscrasia or multiple myeloma, may present in the skin. The commonest findings are spontaneous petechial haemorrhages, purpura and bruising. Such haemorrhage has a predilection for skin with clinically apparent amyloid infiltration: smooth, shiny, waxy, translucent papules and plaques develop, particularly on the eyelids, the neck and in flexural areas. Macroglossia occurs in 10 per cent of cases. |
