Autoimmune movement disorder, autoantibody positive (Q100584): Difference between revisions
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Transtorno de movimento autoimune soropositivo para autoanticorpos neurais._x000D_ Quando esses anticorpos neurais têm como alvo antígenos da membrana plasmática, eles são efetores de lesão (por exemplo, anticorpos do receptor de N-metil-D-aspartato) por meio de múltiplos mecanismos efetores. No entanto, ao alvejar antígenos nucleares ou citoplasmáticos (por exemplo, autoanticorpos complexos de canal de potássio controlado por voltagem), eles são marcadores de uma lesão mediada por células T efetoras, pois são inacessíveis ao ataque imunológico in situ, mas os peptídeos de proteínas intracelulares são exibidos na classe MHC regulada positivamente 1 moléculas em um meio de citocinas pró-inflamatórias e, em seguida, acessíveis a células T citotóxicas específicas de peptídeo._x000D_ _x000D_ Os autoanticorpos neurais associados incluem: DPPX (proteína 6 semelhante a dipeptidil peptidase); GAD65 (anticorpos descarboxilase-65 do ácido glutâmico); NMDA-R (autoanticorpos para o receptor de N-metil-D-aspartato); VGKC (canal de cálcio controlado por voltagem LGI1, CASPR2) | |||
| description / en | description / en | ||
Autoimmune movement disorder seropositive for neural autoantibodies. When these neural antibodies target plasma membrane antigens they are effectors of injury (e.g. N-methyl-D-aspartate receptor antibodies) through multiple effector mechanisms. However, when targeting nuclear or cytoplasmic antigens (e.g. voltage gated-potassium channel complex autoantibodies) they are markers of a T-cell effector mediated injury as they are inaccessible to immune attack in situ, but peptides from intracellular proteins are displayed on upregulated MHC class 1 molecules in a pro-inflammatory cytokine milieu and then accessible to peptide specific cytotoxic T-cells. Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase-like protein-6); GAD65 (glutamic acid decarboxylase-65 antibodies); NMDA-R (N-methyl-D-aspartate receptor autoantibodies); VGKC ( voltage gated calcium channel LGI1, CASPR2) | |||
Revision as of 17:18, 16 August 2026
Autoimmune movement disorder seropositive for neural autoantibodies. When these neural antibodies target plasma membrane antigens they are effectors of injury (e.g. N-methyl-D-aspartate receptor antibodies) through multiple effector mechanisms. However, when targeting nuclear or cytoplasmic antigens (e.g. voltage gated-potassium channel complex autoantibodies) they are markers of a T-cell effector mediated injury as they are inaccessible to immune attack in situ, but peptides from intracellular proteins are displayed on upregulated MHC class 1 molecules in a pro-inflammatory cytokine milieu and then accessible to peptide specific cytotoxic T-cells. Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase-like protein-6); GAD65 (glutamic acid decarboxylase-65 antibodies); NMDA-R (N-methyl-D-aspartate receptor autoantibodies); VGKC ( voltage gated calcium channel LGI1, CASPR2)
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_63677983 |
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| English | Autoimmune movement disorder, autoantibody positive |
Autoimmune movement disorder seropositive for neural autoantibodies. When these neural antibodies target plasma membrane antigens they are effectors of injury (e.g. N-methyl-D-aspartate receptor antibodies) through multiple effector mechanisms. However, when targeting nuclear or cytoplasmic antigens (e.g. voltage gated-potassium channel complex autoantibodies) they are markers of a T-cell effector mediated injury as they are inaccessible to immune attack in situ, but peptides from intracellular proteins are displayed on upregulated MHC class 1 molecules in a pro-inflammatory cytokine milieu and then accessible to peptide specific cytotoxic T-cells. Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase-like protein-6); GAD65 (glutamic acid decarboxylase-65 antibodies); NMDA-R (N-methyl-D-aspartate receptor autoantibodies); VGKC ( voltage gated calcium channel LGI1, CASPR2) |
