{"entities":{"Q100584":{"pageid":90977,"ns":120,"title":"Item:Q100584","lastrevid":574039,"modified":"2026-08-16T17:18:35Z","type":"item","id":"Q100584","labels":{"mul":{"language":"mul","value":"ID_63677983"},"pt-br":{"language":"pt-br","value":"Transtorno do movimento autoimune, autoanticorpo positivo"},"en":{"language":"en","value":"Autoimmune movement disorder, autoantibody positive"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Transtorno de movimento autoimune soropositivo para autoanticorpos neurais._x000D_ Quando esses anticorpos neurais t\u00eam como alvo ant\u00edgenos da membrana plasm\u00e1tica, eles s\u00e3o efetores de les\u00e3o (por exemplo, anticorpos do receptor de N-metil-D-aspartato) por meio de m\u00faltiplos mecanismos efetores. No entanto, ao alvejar ant\u00edgenos nucleares ou citoplasm\u00e1ticos (por exemplo, autoanticorpos complexos de canal de pot\u00e1ssio controlado por voltagem), eles s\u00e3o marcadores de uma les\u00e3o mediada por c\u00e9lulas T efetoras, pois s\u00e3o inacess\u00edveis ao ataque imunol\u00f3gico in situ, mas os pept\u00eddeos de prote\u00ednas intracelulares s\u00e3o exibidos na classe MHC regulada positivamente 1 mol\u00e9culas em um meio de citocinas pr\u00f3-inflamat\u00f3rias e, em seguida, acess\u00edveis a c\u00e9lulas T citot\u00f3xicas espec\u00edficas de pept\u00eddeo._x000D_ _x000D_ Os autoanticorpos neurais associados incluem: DPPX (prote\u00edna 6 semelhante a dipeptidil peptidase); GAD65 (anticorpos descarboxilase-65 do \u00e1cido glut\u00e2mico); NMDA-R (autoanticorpos para o receptor de N-metil-D-aspartato); VGKC (canal de c\u00e1lcio controlado por voltagem LGI1, CASPR2)"},"en":{"language":"en","value":"Autoimmune movement disorder seropositive for neural autoantibodies. When these neural antibodies target plasma membrane antigens they are effectors of injury (e.g. N-methyl-D-aspartate receptor antibodies) through multiple effector mechanisms. However, when targeting nuclear or cytoplasmic antigens (e.g. voltage gated-potassium channel complex autoantibodies) they are markers of a T-cell effector mediated injury as they are inaccessible to immune attack in situ, but peptides from intracellular proteins are displayed on upregulated MHC class 1 molecules in a pro-inflammatory cytokine milieu and then accessible to peptide specific cytotoxic T-cells.  Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase-like protein-6); GAD65 (glutamic acid decarboxylase-65 antibodies); NMDA-R (N-methyl-D-aspartate receptor autoantibodies); VGKC ( voltage gated calcium channel LGI1, CASPR2)"}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"85b55775594e79faa8ad3162f04099a2e1d40e16","datavalue":{"value":"https://id.who.int/icd/entity/63677983","type":"string"},"datatype":"url"},"type":"statement","id":"Q100584$2E655607-D378-452D-B2DD-41C80056934D","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"3ab24371dca47647d353033964cf429f8adbf03b","datavalue":{"value":"CID11:ID_63677983","type":"string"},"datatype":"string"},"type":"statement","id":"Q100584$AD26B050-0FEB-4160-81B5-3FD3C4E2AC72","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"17cf04bf8c4708736b3d3facddab5ba6ba7e5e0c","datavalue":{"value":"dki-india-ID_63677983","type":"string"},"datatype":"string"},"type":"statement","id":"Q100584$DAFA3863-5E4F-447C-B8D5-550CCF4D4128","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q100584$333E79B0-9F55-4537-8622-760A2A7F8CFD","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q100584$E3466DAE-FE8E-4D4F-86A2-324CF5BAE420","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q100584$D667E091-FE37-45EA-B224-095CF2AB0FE7","rank":"normal"}]},"sitelinks":{}}}}