Primary systemic amyloidosis affecting skin or oral cavity (Q96378): Difference between revisions
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A amiloidose sistêmica primária, devido à produção anormal de fragmentos da cadeia leve de imunoglobulina causado pela discrasia das células plasmáticas ou mieloma múltiplo, pode estar presente na pele. Os achados mais comuns são hemorragias petequiais espontâneas, púrpura e hematomas. Essa hemorragia tem predileção pela pele com infiltração amiloide clinicamente aparente: desenvolvem-se pápulas e placas lisas, brilhantes, cerosas e translúcidas, principalmente nas pálpebras, no pescoço e nas áreas que correspondem a locais de flexâo. Macroglossia ocorre em 10 por cento dos casos. | |||
| description / en | description / en | ||
Primary systemic amyloid, due to abnormal secretion of immunoglobulin light chain fragments as a result of plasma cell dyscrasia or multiple myeloma, may present in the skin. The commonest findings are spontaneous petechial haemorrhages, purpura and bruising. Such haemorrhage has a predilection for skin with clinically apparent amyloid infiltration: smooth, shiny, waxy, translucent papules and plaques develop, particularly on the eyelids, the neck and in flexural areas. Macroglossia occurs in 10 per cent of cases. | |||
Revision as of 12:20, 16 August 2026
Primary systemic amyloid, due to abnormal secretion of immunoglobulin light chain fragments as a result of plasma cell dyscrasia or multiple myeloma, may present in the skin. The commonest findings are spontaneous petechial haemorrhages, purpura and bruising. Such haemorrhage has a predilection for skin with clinically apparent amyloid infiltration: smooth, shiny, waxy, translucent papules and plaques develop, particularly on the eyelids, the neck and in flexural areas. Macroglossia occurs in 10 per cent of cases.
| Language | Label | Description | Also known as |
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| default for all languages | ID_848611604 |
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| English | Primary systemic amyloidosis affecting skin or oral cavity |
Primary systemic amyloid, due to abnormal secretion of immunoglobulin light chain fragments as a result of plasma cell dyscrasia or multiple myeloma, may present in the skin. The commonest findings are spontaneous petechial haemorrhages, purpura and bruising. Such haemorrhage has a predilection for skin with clinically apparent amyloid infiltration: smooth, shiny, waxy, translucent papules and plaques develop, particularly on the eyelids, the neck and in flexural areas. Macroglossia occurs in 10 per cent of cases. |
