Myasthenia gravis, AChR antibody positive (Q88659): Difference between revisions
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A miastenia gravis (MG) com autoanticorpos contra o receptor de acetilcolina (AChR) é o tipo de MG mais prevalente. Os anticorpos são direcionados contra proteínas pós-sinápticas, geralmente o receptor nicotínico de acetilcolina, constituindo 80% de todos os pacientes com MG generalizada. A fraqueza flutuante que aumenta com a atividade repetida e melhora após um período de descanso é a manifestação característica. Metade dos pacientes com MG ocular (manifestando-se com ptose e diplopia flutuantes) são AChR positivos. 90% dos pacientes com MG generalizada de início precoce (<40-50 anos), tipicamente mulheres, são positivos para anticorpos AChR e geralmente apresentam hiperplasia do timo. A maioria dos pacientes de início tardio (homens ou mulheres) também são AChR positivos e possuem timo atrófico. | |||
| description / en | description / en | ||
Acetylcholine receptor (AChR) positive Myasthenia Gravis (MG) is the most prevalent type of MG. The antibodies are directed against postsynaptic proteins, usually the nicotinic acetylcholine receptor, making up 80% of all generalised MG patients. Fluctuating weakness increasing with repeated activity and improving after a period of rest is the characteristic hallmark. Half of the ocular MG patients (manifesting with fluctuating ptosis and diplopia) are AChR positive. 90% of early-onset (<40-50 years) generalised MG patients, typically females, are positive for AChR antibodies and usually have thymus hyperplasia. Most late-onset patients (either male or female) are also AChR positive and have atrophic thymuses. | |||
Revision as of 15:00, 15 August 2026
Acetylcholine receptor (AChR) positive Myasthenia Gravis (MG) is the most prevalent type of MG. The antibodies are directed against postsynaptic proteins, usually the nicotinic acetylcholine receptor, making up 80% of all generalised MG patients. Fluctuating weakness increasing with repeated activity and improving after a period of rest is the characteristic hallmark. Half of the ocular MG patients (manifesting with fluctuating ptosis and diplopia) are AChR positive. 90% of early-onset (<40-50 years) generalised MG patients, typically females, are positive for AChR antibodies and usually have thymus hyperplasia. Most late-onset patients (either male or female) are also AChR positive and have atrophic thymuses.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_353120348 |
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| English | Myasthenia gravis, AChR antibody positive |
Acetylcholine receptor (AChR) positive Myasthenia Gravis (MG) is the most prevalent type of MG. The antibodies are directed against postsynaptic proteins, usually the nicotinic acetylcholine receptor, making up 80% of all generalised MG patients. Fluctuating weakness increasing with repeated activity and improving after a period of rest is the characteristic hallmark. Half of the ocular MG patients (manifesting with fluctuating ptosis and diplopia) are AChR positive. 90% of early-onset (<40-50 years) generalised MG patients, typically females, are positive for AChR antibodies and usually have thymus hyperplasia. Most late-onset patients (either male or female) are also AChR positive and have atrophic thymuses. |
