{"entities":{"Q88659":{"pageid":79044,"ns":120,"title":"Item:Q88659","lastrevid":488190,"modified":"2026-08-15T15:00:39Z","type":"item","id":"Q88659","labels":{"mul":{"language":"mul","value":"ID_353120348"},"pt-br":{"language":"pt-br","value":"Miastenia gravis, anticorpo AChR positivo"},"en":{"language":"en","value":"Myasthenia gravis, AChR antibody positive"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A miastenia gravis (MG) com autoanticorpos contra o receptor de acetilcolina (AChR) \u00e9 o tipo de MG mais prevalente. Os anticorpos s\u00e3o direcionados contra prote\u00ednas p\u00f3s-sin\u00e1pticas, geralmente o receptor nicot\u00ednico de acetilcolina, constituindo 80% de todos os pacientes com MG generalizada. A fraqueza flutuante que aumenta com a atividade repetida e melhora ap\u00f3s um per\u00edodo de descanso \u00e9 a manifesta\u00e7\u00e3o caracter\u00edstica. Metade dos pacientes com MG ocular (manifestando-se com ptose e diplopia flutuantes) s\u00e3o AChR positivos. 90% dos pacientes com MG generalizada de in\u00edcio precoce (<40-50 anos), tipicamente mulheres, s\u00e3o positivos para anticorpos AChR e geralmente apresentam hiperplasia do timo. A maioria dos pacientes de in\u00edcio tardio (homens ou mulheres) tamb\u00e9m s\u00e3o AChR positivos e possuem timo atr\u00f3fico."},"en":{"language":"en","value":"Acetylcholine receptor (AChR) positive Myasthenia Gravis (MG) is the most prevalent type of MG. The antibodies are directed against postsynaptic proteins, usually the nicotinic acetylcholine receptor, making up 80% of all generalised MG patients. Fluctuating weakness increasing with repeated activity and improving after a period of rest is the characteristic hallmark. Half of the ocular MG patients (manifesting with fluctuating ptosis and diplopia) are AChR positive. 90% of early-onset (<40-50 years) generalised MG patients, typically females, are positive for AChR antibodies and usually have thymus hyperplasia. Most late-onset patients (either male or female) are also AChR positive and have atrophic thymuses."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"7edcf5a2ca43ea1f25ef87a6f260b0c7a8b58345","datavalue":{"value":"https://id.who.int/icd/entity/353120348","type":"string"},"datatype":"url"},"type":"statement","id":"Q88659$E3A8235E-F99E-47DB-A111-6FC51B2A7B01","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"ac6d78dd307712ed35062e9e526dbf06ceeb209f","datavalue":{"value":"CID11:ID_353120348","type":"string"},"datatype":"string"},"type":"statement","id":"Q88659$D78AF200-DEBB-435F-8297-FF537CA79B09","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"4ca53e2074487f8085a59bfa422584e7ee5fad49","datavalue":{"value":"dki-india-ID_353120348","type":"string"},"datatype":"string"},"type":"statement","id":"Q88659$0AA150D7-95D9-44D2-97F0-100786B38119","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q88659$0C5186AE-BA76-4F45-950F-5029EB5AB683","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q88659$BA48230C-3587-4D7E-9245-E5B96E517DE8","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q88659$523E1B6D-7083-4078-8D48-9296559C037E","rank":"normal"}]},"sitelinks":{}}}}