Congenital plasminogen activator inhibitor type 1 deficiency (Q39607): Difference between revisions
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A deficiência congênita do inibidor do ativador do plasminogênio tecidual tipo 1 (PAI-1) é um transtorno que causa lise prematura de coágulos hemostáticos e uma síndrome hemorrágica moderada. Sangramento espontâneo é raramente observado, enquanto hemorragias moderadas nos joelhos, cotovelos, nariz e gengiva são habitualmente desencadeadas por trauma leve. Entretanto, o sangramento menstrual pode ser grave, e um sangramento prolongado após cirurgia é comum. A deficiência do PAI-1 pode ser qualitativa ou quantitativa, total ou parcial. | |||
| description / en | description / en | ||
Congenital plasminogen activator inhibitor type 1 (PAI-1) deficiency is a disorder that causes premature lysis of haemostatic clots and a moderate bleeding syndrome. Spontaneous bleeding is rarely observed, whereas moderate haemorrhages of the knees, elbows, nose and gingiva are usually triggered by mild trauma. However, menstrual bleeding may be severe and a prolonged bleeding after surgery is common. The PAI-1 deficiency may be qualitative or quantitative, total or partial. | |||
Revision as of 05:05, 13 August 2026
Congenital plasminogen activator inhibitor type 1 (PAI-1) deficiency is a disorder that causes premature lysis of haemostatic clots and a moderate bleeding syndrome. Spontaneous bleeding is rarely observed, whereas moderate haemorrhages of the knees, elbows, nose and gingiva are usually triggered by mild trauma. However, menstrual bleeding may be severe and a prolonged bleeding after surgery is common. The PAI-1 deficiency may be qualitative or quantitative, total or partial.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 3B50.1 |
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| English | Congenital plasminogen activator inhibitor type 1 deficiency |
Congenital plasminogen activator inhibitor type 1 (PAI-1) deficiency is a disorder that causes premature lysis of haemostatic clots and a moderate bleeding syndrome. Spontaneous bleeding is rarely observed, whereas moderate haemorrhages of the knees, elbows, nose and gingiva are usually triggered by mild trauma. However, menstrual bleeding may be severe and a prolonged bleeding after surgery is common. The PAI-1 deficiency may be qualitative or quantitative, total or partial. |
