Scleroedema (Q96788): Difference between revisions

Scleroedema is characterised by diffuse induration of the dermis and subcutis normally affecting just the upper half of the body. The woody infiltration of the skin is due both to infiltration by hyaluronan and to increased collagen synthesis. Histologically the epidermis is unaffected but the dermis is thickened with swelling and separation of collagen bundles and variable amounts of mucin deposited in the deep dermis and subcutis. There are several distinct clinical forms of scleroedema with different aetiological associations and disease courses.