Kaschin-Beck disease due to selenium deficiency (Q94487): Difference between revisions
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A doença de Kaschin-Beck é uma doença óssea e articular (osteoartropatia) responsiva ao selênio detectada em crianças de 5 a 13 anos na China e menos extensivamente no sudeste da Sibéria. A doença é caracterizada por necrose articular - degeneração epifisária das articulações do braço e da perna, resultando em encurtamento estrutural dos dedos e ossos longos com consequente retardo de crescimento e atrofia. Embora não seja idêntica à doença de Keshan, a doença de Kaschin-Beck também ocorre em áreas onde a disponibilidade de selênio no solo para o crescimento da cultura de grãos é baixa. O conteúdo de selênio no cabelo e no sangue total está anormalmente baixo e o conteúdo de glutationa peroxidase (GSHPx) no sangue é reduzido. Embora a doença seja atenuada pela terapia com selênio, outros fatores, como a presença frequente de micotoxinas em grãos de cereais cultivados na área, também podem estar envolvidos. | |||
| description / en | description / en | ||
Kaschin-Beck disease is a selenium-responsive bone and joint disease (osteoarthropathy) detected in children aged 5–13 years in China and less extensively in Southeast Siberia. The disease is characterised by joint necrosis—epiphyseal degeneration of the arm and leg joints resulting in structural shortening of the fingers and long bones with consequent growth retardation and stunting. Although not identical to Keshan disease, Kaschin-Beck disease also occurs in areas where the availability of soil selenium for crop growth is low. The selenium contents of hair and of whole blood are abnormally low and the blood content of glutathione peroxidase (GSHPx) is reduced. Although the disease is ameliorated by selenium therapy, other factors such as the frequent presence of mycotoxins in cereal grains grown in the area may be involved. | |||
Revision as of 09:38, 16 August 2026
Kaschin-Beck disease is a selenium-responsive bone and joint disease (osteoarthropathy) detected in children aged 5–13 years in China and less extensively in Southeast Siberia. The disease is characterised by joint necrosis—epiphyseal degeneration of the arm and leg joints resulting in structural shortening of the fingers and long bones with consequent growth retardation and stunting. Although not identical to Keshan disease, Kaschin-Beck disease also occurs in areas where the availability of soil selenium for crop growth is low. The selenium contents of hair and of whole blood are abnormally low and the blood content of glutathione peroxidase (GSHPx) is reduced. Although the disease is ameliorated by selenium therapy, other factors such as the frequent presence of mycotoxins in cereal grains grown in the area may be involved.
| Language | Label | Description | Also known as |
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| default for all languages | ID_1199186127 |
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| English | Kaschin-Beck disease due to selenium deficiency |
Kaschin-Beck disease is a selenium-responsive bone and joint disease (osteoarthropathy) detected in children aged 5–13 years in China and less extensively in Southeast Siberia. The disease is characterised by joint necrosis—epiphyseal degeneration of the arm and leg joints resulting in structural shortening of the fingers and long bones with consequent growth retardation and stunting. Although not identical to Keshan disease, Kaschin-Beck disease also occurs in areas where the availability of soil selenium for crop growth is low. The selenium contents of hair and of whole blood are abnormally low and the blood content of glutathione peroxidase (GSHPx) is reduced. Although the disease is ameliorated by selenium therapy, other factors such as the frequent presence of mycotoxins in cereal grains grown in the area may be involved. |
