{"entities":{"Q94487":{"pageid":84880,"ns":120,"title":"Item:Q94487","lastrevid":530039,"modified":"2026-08-16T09:38:20Z","type":"item","id":"Q94487","labels":{"mul":{"language":"mul","value":"ID_1199186127"},"pt-br":{"language":"pt-br","value":"Doen\u00e7a de Kaschin-Beck devido \u00e0 defici\u00eancia de sel\u00eanio"},"en":{"language":"en","value":"Kaschin-Beck disease due to selenium deficiency"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A doen\u00e7a de Kaschin-Beck \u00e9 uma doen\u00e7a \u00f3ssea e articular (osteoartropatia) responsiva ao sel\u00eanio detectada em crian\u00e7as de 5 a 13 anos na China e menos extensivamente no sudeste da Sib\u00e9ria. A doen\u00e7a \u00e9 caracterizada por necrose articular - degenera\u00e7\u00e3o epifis\u00e1ria das articula\u00e7\u00f5es do bra\u00e7o e da perna, resultando em encurtamento estrutural dos dedos e ossos longos com consequente retardo de crescimento e atrofia. Embora n\u00e3o seja id\u00eantica \u00e0 doen\u00e7a de Keshan, a doen\u00e7a de Kaschin-Beck tamb\u00e9m ocorre em \u00e1reas onde a disponibilidade de sel\u00eanio no solo para o crescimento da cultura de gr\u00e3os \u00e9 baixa. O conte\u00fado de sel\u00eanio no cabelo e no sangue total est\u00e1 anormalmente baixo e o conte\u00fado de glutationa peroxidase (GSHPx) no sangue \u00e9 reduzido. Embora a doen\u00e7a seja atenuada pela terapia com sel\u00eanio, outros fatores, como a presen\u00e7a frequente de micotoxinas em gr\u00e3os de cereais cultivados na \u00e1rea, tamb\u00e9m podem estar envolvidos."},"en":{"language":"en","value":"Kaschin-Beck disease is a selenium-responsive bone and joint disease (osteoarthropathy) detected in children aged 5\u201313 years in China and less extensively in Southeast Siberia. The disease is characterised by joint necrosis\u2014epiphyseal degeneration of the arm and leg joints resulting in structural shortening of the fingers and long bones with consequent growth retardation and stunting. Although not identical to Keshan disease, Kaschin-Beck disease also occurs in areas where the availability of soil selenium for crop growth is low. The selenium contents of hair and of whole blood are abnormally low and the blood content of glutathione peroxidase (GSHPx) is reduced. Although the disease is ameliorated by selenium therapy, other factors such as the frequent presence of mycotoxins in cereal grains grown in the area may be involved."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"4acc9516cfcd4cf5c57a90012070c7906bdbd526","datavalue":{"value":"https://id.who.int/icd/entity/1199186127","type":"string"},"datatype":"url"},"type":"statement","id":"Q94487$17A40515-DE8B-45AE-93BC-52B4BFC25544","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"dc9c6837b949523a2a32788ce26463c529af9b8c","datavalue":{"value":"CID11:ID_1199186127","type":"string"},"datatype":"string"},"type":"statement","id":"Q94487$C505516C-129E-4221-92A6-3B4C935D0698","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"50fdbc409f2890cbc0053d91473a4d33e3c15204","datavalue":{"value":"dki-india-ID_1199186127","type":"string"},"datatype":"string"},"type":"statement","id":"Q94487$0EE30CC4-DB3B-4BA3-95A0-E97D6C2B513C","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q94487$F11700FE-0711-43A3-A4BA-420CD8D0F312","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q94487$835125BD-F402-4B7B-8604-9C465C429563","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q94487$669D6D32-032D-42EE-952E-83DC85379B6D","rank":"normal"}]},"sitelinks":{}}}}