Amyotrophic lateral sclerosis with frontotemporal dementia (Q86922): Difference between revisions
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Comprometimento cognitivo e mudanças de comportamento refletindo particularmente uma disfunção de funções do lobo frontal, como planejamento, funções executivas e execução de tarefas sequenciais complexas, ocorrem em uma proporção de pacientes com ELA. Existe um continuum, variando de mudanças leves a franca demência frontotemporal (DFT). Exames de neuroimagem podem demonstrar atrofia, hipoperfusão e hipometabolismo dos lobos frontal e temporal. Pacientes com expansões C9ORF72 podem apresentar DFT, ELA ou síndromes de sobreposição. | |||
| description / en | description / en | ||
Cognitive impairment and behaviour changes particularly reflecting dysfunction of frontal lobe functions, such as planning, executive functions, and performing complex sequential tasks, occur in a proportion of ALS patients. There is a continuum, ranging from mild changes to frank frontotemporal dementia (FTD). Neuroimaging may demonstrate atrophy, hypoperfusion, and hypometabolism of frontal and temporal lobes. Patients with C9ORF72 expansions may present with FTD, ALS or overlap syndromes. | |||
Revision as of 12:29, 15 August 2026
Cognitive impairment and behaviour changes particularly reflecting dysfunction of frontal lobe functions, such as planning, executive functions, and performing complex sequential tasks, occur in a proportion of ALS patients. There is a continuum, ranging from mild changes to frank frontotemporal dementia (FTD). Neuroimaging may demonstrate atrophy, hypoperfusion, and hypometabolism of frontal and temporal lobes. Patients with C9ORF72 expansions may present with FTD, ALS or overlap syndromes.
| Language | Label | Description | Also known as |
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| default for all languages | ID_2134326880 |
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| English | Amyotrophic lateral sclerosis with frontotemporal dementia |
Cognitive impairment and behaviour changes particularly reflecting dysfunction of frontal lobe functions, such as planning, executive functions, and performing complex sequential tasks, occur in a proportion of ALS patients. There is a continuum, ranging from mild changes to frank frontotemporal dementia (FTD). Neuroimaging may demonstrate atrophy, hypoperfusion, and hypometabolism of frontal and temporal lobes. Patients with C9ORF72 expansions may present with FTD, ALS or overlap syndromes. |
