Anti-NMDA receptor encephalitis (Q84152): Difference between revisions
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A encefalite do receptor anti-N-metil-D-aspartato (NMDA) resulta de um ataque direcionado ao sistema nervoso central que, em muitos casos, ocorre como consequência de uma resposta imunológica tumoral iniciada por antígenos onco-neurais derivados de um câncer (teratoma) . Afeta mais frequentemente mulheres jovens que apresentam inicialmente características psiquiátricas que, em seguida, progridem para encefalite límbica acompanhada de convulsões, transtornoss do movimento e hipoventilação. Os anticorpos anti-receptor NMDA mais bem detectados no líquido cefalorraquidiano são necessários para o diagnóstico e são frequentemente acompanhados por um teratoma subjacente (geralmente ovariano). Apesar da apresentação inicial grave com manejo de suporte, o tratamento do tumor e a imunoterapia com boa recuperação neurológica são frequentemente alcançáveis. | |||
| description / en | description / en | ||
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis results from a targeted attack on the central nervous system that in many cases occurs as a consequence of a tumour immune response initiated by onco-neural antigens derived from a cancer (teratoma). It most often affects young women who present initially with psychiatric features which then progress to limbic encephalitis with accompanying seizures, movement disorders and hypoventilation. Anti-NMDA-receptor antibodies best detected in cerebrospinal fluid are required for the diagnosis and are frequently accompanied by an underlying teratoma (usually ovarian). Despite the severe initial presentation with supportive management, treatment of tumour and immunotherapy good neurological recovery is frequently achievable. | |||
Revision as of 09:30, 15 August 2026
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis results from a targeted attack on the central nervous system that in many cases occurs as a consequence of a tumour immune response initiated by onco-neural antigens derived from a cancer (teratoma). It most often affects young women who present initially with psychiatric features which then progress to limbic encephalitis with accompanying seizures, movement disorders and hypoventilation. Anti-NMDA-receptor antibodies best detected in cerebrospinal fluid are required for the diagnosis and are frequently accompanied by an underlying teratoma (usually ovarian). Despite the severe initial presentation with supportive management, treatment of tumour and immunotherapy good neurological recovery is frequently achievable.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_1568915618 |
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| English | Anti-NMDA receptor encephalitis |
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis results from a targeted attack on the central nervous system that in many cases occurs as a consequence of a tumour immune response initiated by onco-neural antigens derived from a cancer (teratoma). It most often affects young women who present initially with psychiatric features which then progress to limbic encephalitis with accompanying seizures, movement disorders and hypoventilation. Anti-NMDA-receptor antibodies best detected in cerebrospinal fluid are required for the diagnosis and are frequently accompanied by an underlying teratoma (usually ovarian). Despite the severe initial presentation with supportive management, treatment of tumour and immunotherapy good neurological recovery is frequently achievable. |
