{"entities":{"Q84152":{"pageid":74537,"ns":120,"title":"Item:Q84152","lastrevid":455419,"modified":"2026-08-15T09:30:59Z","type":"item","id":"Q84152","labels":{"mul":{"language":"mul","value":"ID_1568915618"},"pt-br":{"language":"pt-br","value":"Encefalite anti-receptor NMDA"},"en":{"language":"en","value":"Anti-NMDA receptor encephalitis"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A encefalite do receptor anti-N-metil-D-aspartato (NMDA) resulta de um ataque direcionado ao sistema nervoso central que, em muitos casos, ocorre como consequ\u00eancia de uma resposta imunol\u00f3gica tumoral iniciada por ant\u00edgenos onco-neurais derivados de um c\u00e2ncer (teratoma) . Afeta mais frequentemente mulheres jovens que apresentam inicialmente caracter\u00edsticas psiqui\u00e1tricas que, em seguida, progridem para encefalite l\u00edmbica acompanhada de convuls\u00f5es, transtornoss do movimento e hipoventila\u00e7\u00e3o. Os anticorpos anti-receptor NMDA mais bem detectados no l\u00edquido cefalorraquidiano s\u00e3o necess\u00e1rios para o diagn\u00f3stico e s\u00e3o frequentemente acompanhados por um teratoma subjacente (geralmente ovariano). Apesar da apresenta\u00e7\u00e3o inicial grave com manejo de suporte, o tratamento do tumor e a imunoterapia com boa recupera\u00e7\u00e3o neurol\u00f3gica s\u00e3o frequentemente alcan\u00e7\u00e1veis."},"en":{"language":"en","value":"Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis results from a targeted attack on the central nervous system that in many cases occurs as a consequence of a tumour immune response initiated by onco-neural antigens derived from a cancer (teratoma). It most often affects young women who present initially with psychiatric features which then progress to limbic encephalitis with accompanying seizures, movement disorders and hypoventilation. Anti-NMDA-receptor antibodies best detected in cerebrospinal fluid are required for the diagnosis and are frequently accompanied by an underlying teratoma (usually ovarian). Despite the severe initial presentation with supportive management, treatment of tumour and immunotherapy good neurological recovery is frequently achievable."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"7bbc6b37fc69508a7afb058aee724f93263596e9","datavalue":{"value":"https://id.who.int/icd/entity/1568915618","type":"string"},"datatype":"url"},"type":"statement","id":"Q84152$AA32A65E-32F0-47E4-9531-4585AAEF4188","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"e9207760ca339cbf7b8d43d4ff3a8d376ba6fd6a","datavalue":{"value":"CID11:ID_1568915618","type":"string"},"datatype":"string"},"type":"statement","id":"Q84152$82930EC7-9381-4696-AF31-1F74C524E5AD","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"310c6a60973dd754ae8e9917c739da637803ebbc","datavalue":{"value":"dki-india-ID_1568915618","type":"string"},"datatype":"string"},"type":"statement","id":"Q84152$9EBB6895-F1A9-48BA-8445-BF44D92F776D","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84152$C02B8AFF-9C97-4EB6-9A4A-B6A428C36E45","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84152$A378EC1A-3C2C-4DAC-81EE-0CC2828371F8","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84152$F774E3B9-BC09-4B55-8866-424E28B4B46F","rank":"normal"}]},"sitelinks":{}}}}