Autoimmune movement disorder (Q84148): Difference between revisions
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Os transtornos do movimento autoimune são distúrbios inflamatórios imunomediados do sistema nervoso central que podem responder à imunoterapia e não estão associados ao câncer. Eles podem ser pós-infecciosos (por exemplo, coreia de Sydenhams) e normalmente se apresentam com hipocinética subaguda (parkinsonismo [acinesia, bradicinesia, rigidez ou instabilidade postural]) ou distúrbios do movimento hipercinéticos (coreia, tremor [núcleos cerebelares / basais associados], distonia ou mioclonia). A ressonância magnética pode revelar anormalidades do sinal T2 nos núcleos da base e o líquido cefalorraquiano pode ser inflamatório (contagem elevada de leucócitos, proteína acentuadamente elevada ou excesso de bandas oligoclonais). Autoanticorpos específicos neurais são raramente detectados, embora autoanticorpos não específicos de órgãos (por exemplo, autoanticorpos antifosfolipídeos) ocorram com frequência._x000D_ _x000D_ Os autoanticorpos neurais associados incluem:_x000D_ _x000D_ DPPX (proteína semelhante a dipeptidil peptidase-6), GAD65 (anticorpos de descarboxilase-65 do ácido glutâmico), NMDA-R (autoanticorpos do receptor de N-metil-D-aspartato), VGKC (LGI1, CASPR2) anticorpos de canal de potássio com restrição de voltagem. | |||
| description / en | description / en | ||
Autoimmune movement disorders are immune-mediated inflammatory disorders of the central nervous that may respond to immunotherapy and are not associated with cancer. They may be post-infectious (e.g. Sydenhams chorea) and typically present with sub-acute hypokinetic (parkinsonism [akinesia, bradykinesia, rigidity or postural instability]) or hyperkinetic (chorea, tremor [cerebellar/basal ganglia associated], dystonia or myoclonus) movement disorders. MRI may reveal T2-signal abnormalities in the basal ganglia and spinal fluid may be inflammatory (elevated white cell count, markedly elevated protein or excess oligoclonal bands). Neural specific autoantibodies are rarely detected although non-organ specific autoantibodies (e.g. anti-phospholipid autoantibodies) occur frequently. Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase–like protein-6), GAD65 (glutamic acid decarboxylase-65 antibodies), NMDA-R (N-methyl-D-aspartate receptor autoantibodies),VGKC (LGI1, CASPR2) voltage gated potassium channel antibodies. | |||
Revision as of 09:30, 15 August 2026
Autoimmune movement disorders are immune-mediated inflammatory disorders of the central nervous that may respond to immunotherapy and are not associated with cancer. They may be post-infectious (e.g. Sydenhams chorea) and typically present with sub-acute hypokinetic (parkinsonism [akinesia, bradykinesia, rigidity or postural instability]) or hyperkinetic (chorea, tremor [cerebellar/basal ganglia associated], dystonia or myoclonus) movement disorders. MRI may reveal T2-signal abnormalities in the basal ganglia and spinal fluid may be inflammatory (elevated white cell count, markedly elevated protein or excess oligoclonal bands). Neural specific autoantibodies are rarely detected although non-organ specific autoantibodies (e.g. anti-phospholipid autoantibodies) occur frequently. Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase–like protein-6), GAD65 (glutamic acid decarboxylase-65 antibodies), NMDA-R (N-methyl-D-aspartate receptor autoantibodies),VGKC (LGI1, CASPR2) voltage gated potassium channel antibodies.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_1557930774 |
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| English | Autoimmune movement disorder |
Autoimmune movement disorders are immune-mediated inflammatory disorders of the central nervous that may respond to immunotherapy and are not associated with cancer. They may be post-infectious (e.g. Sydenhams chorea) and typically present with sub-acute hypokinetic (parkinsonism [akinesia, bradykinesia, rigidity or postural instability]) or hyperkinetic (chorea, tremor [cerebellar/basal ganglia associated], dystonia or myoclonus) movement disorders. MRI may reveal T2-signal abnormalities in the basal ganglia and spinal fluid may be inflammatory (elevated white cell count, markedly elevated protein or excess oligoclonal bands). Neural specific autoantibodies are rarely detected although non-organ specific autoantibodies (e.g. anti-phospholipid autoantibodies) occur frequently. Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase–like protein-6), GAD65 (glutamic acid decarboxylase-65 antibodies), NMDA-R (N-methyl-D-aspartate receptor autoantibodies),VGKC (LGI1, CASPR2) voltage gated potassium channel antibodies. |
