{"entities":{"Q84148":{"pageid":74533,"ns":120,"title":"Item:Q84148","lastrevid":455388,"modified":"2026-08-15T09:30:44Z","type":"item","id":"Q84148","labels":{"mul":{"language":"mul","value":"ID_1557930774"},"pt-br":{"language":"pt-br","value":"Transtorno de movimento autoimune"},"en":{"language":"en","value":"Autoimmune movement disorder"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Os transtornos do movimento autoimune s\u00e3o dist\u00farbios inflamat\u00f3rios imunomediados do sistema nervoso central que podem responder \u00e0 imunoterapia e n\u00e3o est\u00e3o associados ao c\u00e2ncer. Eles podem ser p\u00f3s-infecciosos (por exemplo, coreia de Sydenhams) e normalmente se apresentam com hipocin\u00e9tica subaguda (parkinsonismo [acinesia, bradicinesia, rigidez ou instabilidade postural]) ou dist\u00farbios do movimento hipercin\u00e9ticos (coreia, tremor [n\u00facleos cerebelares / basais associados], distonia ou mioclonia). A resson\u00e2ncia magn\u00e9tica pode revelar anormalidades do sinal T2 nos n\u00facleos da base e o l\u00edquido cefalorraquiano pode ser inflamat\u00f3rio (contagem elevada de leuc\u00f3citos, prote\u00edna acentuadamente elevada ou excesso de bandas oligoclonais). Autoanticorpos espec\u00edficos neurais s\u00e3o raramente detectados, embora autoanticorpos n\u00e3o espec\u00edficos de \u00f3rg\u00e3os (por exemplo, autoanticorpos antifosfolip\u00eddeos) ocorram com frequ\u00eancia._x000D_ _x000D_ Os autoanticorpos neurais associados incluem:_x000D_ _x000D_ DPPX (prote\u00edna semelhante a dipeptidil peptidase-6), GAD65 (anticorpos de descarboxilase-65 do \u00e1cido glut\u00e2mico), NMDA-R (autoanticorpos do receptor de N-metil-D-aspartato), VGKC (LGI1, CASPR2) anticorpos de canal de pot\u00e1ssio com restri\u00e7\u00e3o de voltagem."},"en":{"language":"en","value":"Autoimmune movement disorders are immune-mediated inflammatory disorders of the central nervous that may respond to immunotherapy and are not associated with cancer. They may be post-infectious (e.g. Sydenhams chorea) and typically present with sub-acute hypokinetic (parkinsonism [akinesia, bradykinesia, rigidity or postural instability]) or hyperkinetic (chorea, tremor [cerebellar/basal ganglia associated], dystonia or myoclonus) movement disorders. MRI may reveal T2-signal abnormalities in the basal ganglia and spinal fluid may be inflammatory (elevated white cell count, markedly elevated protein or excess oligoclonal bands). Neural specific autoantibodies are rarely detected although non-organ specific autoantibodies (e.g. anti-phospholipid autoantibodies) occur frequently.  Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase\u2013like protein-6), GAD65 (glutamic acid decarboxylase-65 antibodies), NMDA-R (N-methyl-D-aspartate receptor autoantibodies),VGKC (LGI1, CASPR2) voltage gated potassium channel antibodies."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"2ba3794ba3e53b661e5d52f5a56536ce78abe86a","datavalue":{"value":"https://id.who.int/icd/entity/1557930774","type":"string"},"datatype":"url"},"type":"statement","id":"Q84148$ACE4FEBC-FCB9-42C6-886B-292AF13A696D","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"37b55bfaaafdfb151ab606ca79644d59dc6983ff","datavalue":{"value":"CID11:ID_1557930774","type":"string"},"datatype":"string"},"type":"statement","id":"Q84148$FFF0C3F2-37FA-45C9-B9E2-8C61E431FF42","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"7f94735d0ab16f620e226dbf63ea634ad35c926a","datavalue":{"value":"dki-india-ID_1557930774","type":"string"},"datatype":"string"},"type":"statement","id":"Q84148$E44B048B-8104-4A77-9A0D-182F5F58FEDE","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84148$35E6B9D1-C3D9-4C6D-9B8E-3BE053F5D47F","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84148$85C4A195-C436-4D0E-9470-6AA0A680C0DE","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84148$E37DCA89-04BA-44C7-B0A2-97AB0B5F0BBF","rank":"normal"}]},"sitelinks":{}}}}