Paraneoplastic retinopathy (Q41745): Difference between revisions
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As retinopatias paraneoplásicas resultam de um ataque direcionado à retina devido a uma resposta imune ao tumor iniciada por antígenos onco-neurais derivados do câncer sistêmico. Os pacientes geralmente se apresentam após o diagnóstico de câncer com escurecimento visual progressivo e fotopsias, mas também podem ocorrer disfunção de bastonetes (adaptação ao escuro prejudicada e perda de visão periférica) e de cones (diminuição da acuidade visual, disfunção de cor, fotossensibilidade e ofuscamento). Os sintomas costumam ser piores do que os sinais clínicos. Outras causas de retinopatia devem ser excluídas. Múltiplos autoanticorpos anti-retinianos (p. ex. anticorpos anti-recoverina) são descritos, embora seu significado seja incerto. Dois subconjuntos principais são reconhecidos: retinopatia associada ao câncer (mais comumente câncer de pulmão de células pequenas) e retinopatia associada ao melanoma._x000D_ _x000D_ Os autoanticorpos neurais associados incluem:_x000D_ _x000D_ CRMP5 (anti-CV2) (proteína 5 do mediador da resposta à colapsina - anti CV2); autoanticorpos anti-recoverina; e auto-anticorpos alfa-enolase. | |||
| description / en | description / en | ||
Paraneoplastic retinopathies result from a targeted attack on the retina due to a tumour immune response initiated by onco-neural antigens derived from systemic cancer. Patients usually present after cancer diagnosis with progressive visual dimming and photopsias but dysfunction of rods (impaired dark adaption and peripheral vision loss) and cones (decreased visual acuity, colour dysfunction, photosensitivity and glare) may also occur. Symptoms are often worse than clinical signs. Other causes of retinopathy should be excluded. Multiple anti-retinal autoantibodies (e.g. anti-recoverin antibodies) are described although their significance is uncertain. Two major subsets are recognised: cancer-associated retinopathy (most commonly small-cell lung cancer) and melanoma-associated retinopathy. Associated neural autoantibodies include: CRMP5 (anti-CV2) (collapsin response mediator protein 5 - anti CV2); anti-recoverin autoantibodies; and alpha-enolase autoantibodies. | |||
Revision as of 08:00, 13 August 2026
Paraneoplastic retinopathies result from a targeted attack on the retina due to a tumour immune response initiated by onco-neural antigens derived from systemic cancer. Patients usually present after cancer diagnosis with progressive visual dimming and photopsias but dysfunction of rods (impaired dark adaption and peripheral vision loss) and cones (decreased visual acuity, colour dysfunction, photosensitivity and glare) may also occur. Symptoms are often worse than clinical signs. Other causes of retinopathy should be excluded. Multiple anti-retinal autoantibodies (e.g. anti-recoverin antibodies) are described although their significance is uncertain. Two major subsets are recognised: cancer-associated retinopathy (most commonly small-cell lung cancer) and melanoma-associated retinopathy. Associated neural autoantibodies include: CRMP5 (anti-CV2) (collapsin response mediator protein 5 - anti CV2); anti-recoverin autoantibodies; and alpha-enolase autoantibodies.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 9B71.4 |
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| English | Paraneoplastic retinopathy |
Paraneoplastic retinopathies result from a targeted attack on the retina due to a tumour immune response initiated by onco-neural antigens derived from systemic cancer. Patients usually present after cancer diagnosis with progressive visual dimming and photopsias but dysfunction of rods (impaired dark adaption and peripheral vision loss) and cones (decreased visual acuity, colour dysfunction, photosensitivity and glare) may also occur. Symptoms are often worse than clinical signs. Other causes of retinopathy should be excluded. Multiple anti-retinal autoantibodies (e.g. anti-recoverin antibodies) are described although their significance is uncertain. Two major subsets are recognised: cancer-associated retinopathy (most commonly small-cell lung cancer) and melanoma-associated retinopathy. Associated neural autoantibodies include: CRMP5 (anti-CV2) (collapsin response mediator protein 5 - anti CV2); anti-recoverin autoantibodies; and alpha-enolase autoantibodies. |
