{"entities":{"Q41745":{"pageid":32113,"ns":120,"title":"Item:Q41745","lastrevid":140709,"modified":"2026-08-13T08:00:58Z","type":"item","id":"Q41745","labels":{"mul":{"language":"mul","value":"9B71.4"},"pt-br":{"language":"pt-br","value":"Retinopatia paraneopl\u00e1sica"},"en":{"language":"en","value":"Paraneoplastic retinopathy"}},"descriptions":{"pt-br":{"language":"pt-br","value":"As retinopatias paraneopl\u00e1sicas resultam de um ataque direcionado \u00e0 retina devido a uma resposta imune ao tumor iniciada por ant\u00edgenos onco-neurais derivados do c\u00e2ncer sist\u00eamico. Os pacientes geralmente se apresentam ap\u00f3s o diagn\u00f3stico de c\u00e2ncer com escurecimento visual progressivo e fotopsias, mas tamb\u00e9m podem ocorrer disfun\u00e7\u00e3o de bastonetes (adapta\u00e7\u00e3o ao escuro prejudicada e perda de vis\u00e3o perif\u00e9rica) e de cones (diminui\u00e7\u00e3o da acuidade visual, disfun\u00e7\u00e3o de cor, fotossensibilidade e ofuscamento). Os sintomas costumam ser piores do que os sinais cl\u00ednicos. Outras causas de retinopatia devem ser exclu\u00eddas. M\u00faltiplos autoanticorpos anti-retinianos (p. ex. anticorpos anti-recoverina) s\u00e3o descritos, embora seu significado seja incerto. Dois subconjuntos principais s\u00e3o reconhecidos: retinopatia associada ao c\u00e2ncer (mais comumente c\u00e2ncer de pulm\u00e3o de c\u00e9lulas pequenas) e retinopatia associada ao melanoma._x000D_ _x000D_ Os autoanticorpos neurais associados incluem:_x000D_ _x000D_ CRMP5 (anti-CV2) (prote\u00edna 5 do mediador da resposta \u00e0 colapsina - anti CV2); autoanticorpos anti-recoverina; e auto-anticorpos alfa-enolase."},"en":{"language":"en","value":"Paraneoplastic retinopathies result from a targeted attack on the retina due to a tumour immune response initiated by onco-neural antigens derived from systemic cancer. Patients usually present after cancer diagnosis with progressive visual dimming and photopsias but dysfunction of rods (impaired dark adaption and peripheral vision loss) and cones (decreased visual acuity, colour dysfunction, photosensitivity and glare) may also occur. Symptoms are often worse than clinical signs. Other causes of retinopathy should be excluded. Multiple anti-retinal autoantibodies (e.g. anti-recoverin antibodies) are described although their significance is uncertain. Two major subsets are recognised: cancer-associated retinopathy (most commonly small-cell lung cancer) and melanoma-associated retinopathy. Associated neural autoantibodies include: CRMP5 (anti-CV2) (collapsin response mediator protein 5 - anti CV2); anti-recoverin autoantibodies; and alpha-enolase autoantibodies."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"699bf304454d411d64a0093f91f3a3509f77e5d1","datavalue":{"value":"https://id.who.int/icd/entity/1216073790","type":"string"},"datatype":"url"},"type":"statement","id":"Q41745$E6CA3F9E-D690-4169-91BF-50F338C0F5BF","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"f4d7feaa3bec080334329a516fefeca0e92fc333","datavalue":{"value":"CID11:9B71.4","type":"string"},"datatype":"string"},"type":"statement","id":"Q41745$5AEDB7FB-E850-4944-B793-7785A4165624","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"c472e86b5acb81a8f0b794fa161feab3658d2946","datavalue":{"value":"dki-india-9B71.4","type":"string"},"datatype":"string"},"type":"statement","id":"Q41745$E58331BB-7B14-4BB0-A91E-E9D2DC1BBD13","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q41745$40AA4BCE-229C-473B-B067-FFC0FA934E56","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q41745$EBFBD929-513E-4660-8F49-AA3F8D308862","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q41745$EB88070E-6489-470F-AEEA-62D890F07B5F","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"5b66d5bb7bf4ceb4d2306d3766ba7f0cecf6aaab","datavalue":{"value":{"entity-type":"item","numeric-id":41719,"id":"Q41719"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q41745$50C99DEE-3BFE-4191-9663-D2744BA9495B","rank":"normal"}]},"sitelinks":{}}}}