Inflammatory inclusion body myositis (Q41416): Difference between revisions
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A miosite por corpos de inclusão (MCI) é a miopatia inflamatória idiopática mais comum após os 50 anos de idade. Apresenta-se, tipicamente, com fraqueza muscular assimétrica, insidiosa e crônica, proximal de pernas e/ou distal em braços, levando a quedas recorrentes e perda de destreza. A creatinofosfoquinase (CPK) está aumentada em até 15 vezes na MCI e a eletroneuromiografia por agulha mostra principalmente uma miopatia irritativa crônica. A histopatologia do músculo demonstra exsudatos inflamatórios no endomísio circundando e invadindo as fibras musculares não necróticas, muitas vezes acompanhados de vacúolos marginados e depósitos de proteínas. Apesar da histopatologia muscular inflamatória, é provável que a MCI tenha um componente degenerativo proeminente, suportado pela refratariedade à terapia imunossupressora. | |||
| description / en | description / en | ||
Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase is up to 15 times elevated in IBM and needle electromyography mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibres often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology, it is likely that IBM has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy. | |||
Revision as of 07:34, 13 August 2026
Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase is up to 15 times elevated in IBM and needle electromyography mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibres often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology, it is likely that IBM has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 4A41.20 |
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| English | Inflammatory inclusion body myositis |
Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase is up to 15 times elevated in IBM and needle electromyography mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibres often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology, it is likely that IBM has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy. |
