{"entities":{"Q41416":{"pageid":31784,"ns":120,"title":"Item:Q41416","lastrevid":137982,"modified":"2026-08-13T07:34:54Z","type":"item","id":"Q41416","labels":{"mul":{"language":"mul","value":"4A41.20"},"pt-br":{"language":"pt-br","value":"Miosite por corp\u00fasculos de inclus\u00e3o (inflamat\u00f3ria)"},"en":{"language":"en","value":"Inflammatory inclusion body myositis"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A miosite por corpos de inclus\u00e3o (MCI) \u00e9 a miopatia inflamat\u00f3ria idiop\u00e1tica mais comum ap\u00f3s os 50 anos de idade. Apresenta-se, tipicamente, com fraqueza muscular assim\u00e9trica, insidiosa e cr\u00f4nica, proximal de pernas e/ou distal em bra\u00e7os, levando a quedas recorrentes e perda de destreza. A creatinofosfoquinase (CPK) est\u00e1 aumentada em at\u00e9 15 vezes na MCI e a eletroneuromiografia por agulha mostra principalmente uma miopatia irritativa cr\u00f4nica. A histopatologia do m\u00fasculo demonstra exsudatos inflamat\u00f3rios no endom\u00edsio circundando e invadindo as fibras musculares n\u00e3o necr\u00f3ticas, muitas vezes acompanhados de vac\u00faolos marginados e dep\u00f3sitos de prote\u00ednas. Apesar da histopatologia muscular inflamat\u00f3ria, \u00e9 prov\u00e1vel que a MCI tenha um componente degenerativo proeminente, suportado pela refratariedade \u00e0 terapia imunossupressora."},"en":{"language":"en","value":"Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase is up to 15 times elevated in IBM and needle electromyography mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibres often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology, it is likely that IBM has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"69ac97ed5044fdfa876690b17a76b7acb1b52bf5","datavalue":{"value":"https://id.who.int/icd/entity/797555186","type":"string"},"datatype":"url"},"type":"statement","id":"Q41416$41B15D72-4BD1-41CC-A5A2-D764F45DFE4E","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"552f83b82752355542ccd20098b0fd7189e00080","datavalue":{"value":"CID11:4A41.20","type":"string"},"datatype":"string"},"type":"statement","id":"Q41416$08085810-F463-4500-B36D-ED0F0927FE77","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"9bd52c9ff31189ce2fc995df3ccd3ef6261ff3f3","datavalue":{"value":"dki-india-4A41.20","type":"string"},"datatype":"string"},"type":"statement","id":"Q41416$97C154B5-E4EF-4589-8FEA-BEEBF5C94BFD","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q41416$24373962-743C-4BCE-94C2-A231B99BFD2E","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q41416$BE8CFA4A-6DAB-4381-A457-5BACD61CFA11","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q41416$84704901-591C-4BBC-BB72-1D74F17DC90D","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"ccca9e0c257166df04befe9222120ca9ac35fd8d","datavalue":{"value":{"entity-type":"item","numeric-id":17323,"id":"Q17323"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q41416$6BAF2916-B379-4758-94FA-70A395A7BB0E","rank":"normal"}]},"sitelinks":{}}}}