Motor neuron disease (Q41052): Difference between revisions
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Doença do neurônio motor é um transtorno neurodegenerativo de etiologia indeterminada, caracterizado por degeneração de neurônios motores superiores (células corticais de Betz e trato corticoespinal) ou neurônios motores inferiores (cornos ventrais da medula espinal e núcleos motores dos nervos cranianos) ou ambos. Características de envolvimento dos neurônios motores inferiores (NMI) são atrofia, fraqueza, fasciculações, hipotonia, diminuição ou ausência de reflexos tendinosos profundos. Características de envolvimento dos neurônios motores superiores (NMS) são espasticidade, reflexos tendinosos profundos exacerbados e respostas plantares extensoras. Dependendo da localização de início e da presença de características de NMI ou NMS ou ambos, a DNM têm padrões e distribuições variáveis de sinais e sintomas. | |||
| description / en | description / en | ||
Motor neuron disease is a neurodegenerative disorder of undetermined etiology, characterised by degeneration of upper motor neurons (cortical Betz cells and corticospinal tract) or lower motor neurons (ventral horns of spinal cord and cranial nerve motor nuclei) or both. Features of involvement of lower motor neurons (LMN) are atrophy, weakness, fasciculations, hypotonia, decreased or absent deep tendon reflexes. Features of involvement of upper motor neurons (UMN) are spasticity, exaggerated deep tendon reflexes, and extensor plantar responses. Depending on the site of onset and the presence of UMN or LMN features or both, MND has varying patterns and distributions of signs and symptoms. | |||
Revision as of 07:06, 13 August 2026
Motor neuron disease is a neurodegenerative disorder of undetermined etiology, characterised by degeneration of upper motor neurons (cortical Betz cells and corticospinal tract) or lower motor neurons (ventral horns of spinal cord and cranial nerve motor nuclei) or both. Features of involvement of lower motor neurons (LMN) are atrophy, weakness, fasciculations, hypotonia, decreased or absent deep tendon reflexes. Features of involvement of upper motor neurons (UMN) are spasticity, exaggerated deep tendon reflexes, and extensor plantar responses. Depending on the site of onset and the presence of UMN or LMN features or both, MND has varying patterns and distributions of signs and symptoms.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 8B60 |
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| English | Motor neuron disease |
Motor neuron disease is a neurodegenerative disorder of undetermined etiology, characterised by degeneration of upper motor neurons (cortical Betz cells and corticospinal tract) or lower motor neurons (ventral horns of spinal cord and cranial nerve motor nuclei) or both. Features of involvement of lower motor neurons (LMN) are atrophy, weakness, fasciculations, hypotonia, decreased or absent deep tendon reflexes. Features of involvement of upper motor neurons (UMN) are spasticity, exaggerated deep tendon reflexes, and extensor plantar responses. Depending on the site of onset and the presence of UMN or LMN features or both, MND has varying patterns and distributions of signs and symptoms. |
