Biotin deficiency (Q39925): Difference between revisions
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A deficiência isolada de biotina é rara. Sinais de deficiência de biotina em humanos foram demonstrados em indivíduos que consomem clara de ovo crua por longos períodos e em nutrição parenteral total (NPT), antes da suplementação de biotina, além de pacientes com má absorção. Os achados clínicos da deficiência de biotina incluem dermatite, conjuntivite, alopecia e anormalidades do sistema nervoso central. Em adultos alimentados com clara de ovo crua (que contém avidina, uma proteína que se liga à biotina com alta afinidade tornando-a indisponível biologicamente ) ou recebendo NPT sem biotina por meses a anos, o enfraquecimento do cabelo, frequentemente com perda da cor do cabelo, tem sido relatado. A maioria dos adultos com deficiência apresenta erupções cutâneas vermelhas e escamosas, frequentemente ao redor dos olhos, nariz e boca. A maioria dos adultos apresenta sintomas neurológicos, incluindo depressão, letargia, alucinações e parestesia das extremidades. | |||
| description / en | description / en | ||
Isolated biotin deficiency is rare. Signs of biotin deficiency in humans have been demonstrated in individuals who consume raw egg white over long periods and in total parenteral nutrition (TPN) before biotin supplementation in patients with malabsorption. The clinical findings of biotin deficiency include dermatitis, conjunctivitis, alopecia, and central nervous system abnormalities. In adults fed raw egg white (which contains avidin, a protein that binds biotin with such high affinity that it renders it biounavailable) or receiving biotin-free TPN for months to years, thinning of hair, frequently with loss of hair colour, has been reported. Most adults with the deficiency demonstrate a red, scaly, skin rash, frequently around the eyes, nose, and mouth. Most of the adults have neurological symptoms, including depression, lethargy, hallucinations, and paraesthesia of the extremities. | |||
Revision as of 05:31, 13 August 2026
Isolated biotin deficiency is rare. Signs of biotin deficiency in humans have been demonstrated in individuals who consume raw egg white over long periods and in total parenteral nutrition (TPN) before biotin supplementation in patients with malabsorption. The clinical findings of biotin deficiency include dermatitis, conjunctivitis, alopecia, and central nervous system abnormalities. In adults fed raw egg white (which contains avidin, a protein that binds biotin with such high affinity that it renders it biounavailable) or receiving biotin-free TPN for months to years, thinning of hair, frequently with loss of hair colour, has been reported. Most adults with the deficiency demonstrate a red, scaly, skin rash, frequently around the eyes, nose, and mouth. Most of the adults have neurological symptoms, including depression, lethargy, hallucinations, and paraesthesia of the extremities.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 5B5G |
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| English | Biotin deficiency |
Isolated biotin deficiency is rare. Signs of biotin deficiency in humans have been demonstrated in individuals who consume raw egg white over long periods and in total parenteral nutrition (TPN) before biotin supplementation in patients with malabsorption. The clinical findings of biotin deficiency include dermatitis, conjunctivitis, alopecia, and central nervous system abnormalities. In adults fed raw egg white (which contains avidin, a protein that binds biotin with such high affinity that it renders it biounavailable) or receiving biotin-free TPN for months to years, thinning of hair, frequently with loss of hair colour, has been reported. Most adults with the deficiency demonstrate a red, scaly, skin rash, frequently around the eyes, nose, and mouth. Most of the adults have neurological symptoms, including depression, lethargy, hallucinations, and paraesthesia of the extremities. |
