{"entities":{"Q39925":{"pageid":30293,"ns":120,"title":"Item:Q39925","lastrevid":125009,"modified":"2026-08-13T05:31:58Z","type":"item","id":"Q39925","labels":{"mul":{"language":"mul","value":"5B5G"},"pt-br":{"language":"pt-br","value":"Defici\u00eancia de biotina"},"en":{"language":"en","value":"Biotin deficiency"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A defici\u00eancia isolada de biotina \u00e9 rara. Sinais de defici\u00eancia de biotina em humanos foram demonstrados em indiv\u00edduos que consomem clara de ovo crua por longos per\u00edodos e em nutri\u00e7\u00e3o parenteral total (NPT), antes da suplementa\u00e7\u00e3o de biotina, al\u00e9m de pacientes com m\u00e1 absor\u00e7\u00e3o. Os achados cl\u00ednicos da defici\u00eancia de biotina incluem dermatite, conjuntivite, alopecia e anormalidades do sistema nervoso central. Em adultos alimentados com clara de ovo crua (que cont\u00e9m avidina, uma prote\u00edna que se liga \u00e0 biotina com alta afinidade tornando-a indispon\u00edvel biologicamente ) ou recebendo NPT sem biotina por meses a anos, o enfraquecimento do cabelo, frequentemente com perda da cor do cabelo, tem sido relatado. A maioria dos adultos com defici\u00eancia apresenta erup\u00e7\u00f5es cut\u00e2neas vermelhas e escamosas, frequentemente ao redor dos olhos, nariz e boca. A maioria dos adultos apresenta sintomas neurol\u00f3gicos, incluindo depress\u00e3o, letargia, alucina\u00e7\u00f5es e parestesia das extremidades."},"en":{"language":"en","value":"Isolated biotin deficiency is rare. Signs of biotin deficiency in humans have been demonstrated in individuals who consume raw egg white over long periods and in total parenteral nutrition (TPN) before biotin supplementation in patients with malabsorption. The clinical findings of biotin deficiency include dermatitis, conjunctivitis, alopecia, and central nervous system abnormalities. In adults fed raw egg white (which contains avidin, a protein that binds biotin with such high affinity that it renders it biounavailable) or receiving biotin-free TPN for months to years, thinning of hair, frequently with loss of hair colour, has been reported. Most adults with the deficiency demonstrate a red, scaly, skin rash, frequently around the eyes, nose, and mouth. Most of the adults have neurological symptoms, including depression, lethargy, hallucinations, and paraesthesia of the extremities."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"033d684c8727d46bf6d93f51ce82ecfba2780d92","datavalue":{"value":"https://id.who.int/icd/entity/1726732000","type":"string"},"datatype":"url"},"type":"statement","id":"Q39925$157ABF31-FC65-4B0F-BAA7-30E48DB236A1","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"b209fbde82ab4f235ed1f12f963691b79c1820eb","datavalue":{"value":"CID11:5B5G","type":"string"},"datatype":"string"},"type":"statement","id":"Q39925$935D2A0E-AC37-41B6-A3C5-CA90A11A8B88","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"e8aa661120da486ba8791a912625179e6f84d833","datavalue":{"value":"dki-india-5B5G","type":"string"},"datatype":"string"},"type":"statement","id":"Q39925$8DB2DA0A-6E50-4503-8104-F72E631FC79F","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q39925$DC0C7B1F-B0DF-47BE-8942-81968A1C2412","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q39925$2C89C8EA-71D4-4FCD-8A0F-2F5720F21614","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q39925$CC477B83-1262-4C49-B5E4-56CB2AB78326","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"9aa10c71415692dee869745b2c7652849e0afa6a","datavalue":{"value":{"entity-type":"item","numeric-id":15442,"id":"Q15442"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q39925$D28BD0BA-3F9F-41BD-8027-54D8B6BBCF3B","rank":"normal"}]},"sitelinks":{}}}}