Pulmonary toxoplasmosis due to Toxoplasma gondii (Q38479): Difference between revisions
From determinar.ia.br - Determine suas informações
Created a new Item |
Changed label, description and/or aliases in pt-br, en |
||
| description / pt-br | description / pt-br | ||
Em pacientes imunodeficientes, a toxoplasmose ocorre mais frequentemente em pessoas com defeitos na imunidade mediada por células T, como aqueles que recebem corticosteroides, terapias antifator de necrose tumoral (TNF) ou drogas citotóxicas, e aqueles com doenças hematológicas malignas, transplantes de órgãos ou síndrome de imunodeficiência adquirida (SIDA). _x000D_ A toxoplasmose pulmonar no paciente imunodeficiente pode aparecer na forma de pneumonite intersticial, pneumonite necrotizante, consolidação, derrame pleural ou empiema, ou todos eles. _x000D_ Pacientes com SIDA e pneumonia por Toxoplasma apresentam tosse, dispneia e febre. Como a toxoplasmose geralmente é observada apenas na infecção avançada por HIV com contagens de CD4 abaixo de 100, a maioria dos pacientes com SIDA que desenvolvem pneumonia por toxoplasma já teve infecções oportunistas anteriores associadas ao HIV. Em pacientes transplantados de órgãos sólidos, isso ocorre mais comumente devido ao transplante de um pulmão ou coração de um doador soropositivo para toxoplasma para um receptor soronegativo, resultando em doença pulmonar primária. Em pacientes transplantados de medula óssea, a toxoplasmose pulmonar ocorre em 0,28% a 0,45% dos pacientes. Ao contrário dos pacientes com transplante de órgãos sólidos, a maioria desses pacientes apresenta reativação, não doença primária. | |||
| description / en | description / en | ||
In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, or cytotoxic drugs and those with hematologic malignancies, organ transplants, or acquired immunodeficiency syndrome (AIDS). Pulmonary toxoplasmosis in the immunodeficient patient may appear in the form of interstitial pneumonitis, necrotizing pneumonitis, consolidation, pleural effusion, or empyema, or all of these. AIDS patients with Toxoplasma pneumonia present with cough, dyspnoea, and fever. As toxoplasmosis is generally seen only in advanced HIV infection with CD4 counts below 100, the majority of AIDS patients who develop toxoplasma pneumonia already have had previous HIV-associated opportunistic infections. In solid organ transplant patients, this is most commonly due to transplantation of a toxoplasma-seropositive lung or heart into a seronegative recipient, resulting in primary pulmonary disease. In bone marrow transplant patients, pulmonary toxoplasmosis occurs in 0.28% to 0.45% of patients. Unlike solid organ transplant patients, most of these patients have reactivation, not primary disease. | |||
Revision as of 03:33, 13 August 2026
In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, or cytotoxic drugs and those with hematologic malignancies, organ transplants, or acquired immunodeficiency syndrome (AIDS). Pulmonary toxoplasmosis in the immunodeficient patient may appear in the form of interstitial pneumonitis, necrotizing pneumonitis, consolidation, pleural effusion, or empyema, or all of these. AIDS patients with Toxoplasma pneumonia present with cough, dyspnoea, and fever. As toxoplasmosis is generally seen only in advanced HIV infection with CD4 counts below 100, the majority of AIDS patients who develop toxoplasma pneumonia already have had previous HIV-associated opportunistic infections. In solid organ transplant patients, this is most commonly due to transplantation of a toxoplasma-seropositive lung or heart into a seronegative recipient, resulting in primary pulmonary disease. In bone marrow transplant patients, pulmonary toxoplasmosis occurs in 0.28% to 0.45% of patients. Unlike solid organ transplant patients, most of these patients have reactivation, not primary disease.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | 1F57.2 |
||
| English | Pulmonary toxoplasmosis due to Toxoplasma gondii |
In immunodeficient patients, toxoplasmosis most often occurs in persons with defects in T cell–mediated immunity such as those receiving corticosteroids, anti–tumour necrosis factor (TNF) therapies, or cytotoxic drugs and those with hematologic malignancies, organ transplants, or acquired immunodeficiency syndrome (AIDS). Pulmonary toxoplasmosis in the immunodeficient patient may appear in the form of interstitial pneumonitis, necrotizing pneumonitis, consolidation, pleural effusion, or empyema, or all of these. AIDS patients with Toxoplasma pneumonia present with cough, dyspnoea, and fever. As toxoplasmosis is generally seen only in advanced HIV infection with CD4 counts below 100, the majority of AIDS patients who develop toxoplasma pneumonia already have had previous HIV-associated opportunistic infections. In solid organ transplant patients, this is most commonly due to transplantation of a toxoplasma-seropositive lung or heart into a seronegative recipient, resulting in primary pulmonary disease. In bone marrow transplant patients, pulmonary toxoplasmosis occurs in 0.28% to 0.45% of patients. Unlike solid organ transplant patients, most of these patients have reactivation, not primary disease. |
