Paraneoplastic cerebellar degeneration (Q84135): Difference between revisions

@@ description / pt-br / description / pt-br @@
+A degeneração cerebelar paraneoplásica resulta de um ataque direcionado ao tronco cerebral como consequência de uma resposta imune tumoral potencialmente eficaz iniciada por antígenos onco-neurais derivados de um câncer sistêmico. Os pacientes se apresentam de forma subaguda com sintomas e sinais atribuíveis ao cerebelo. As manifestações neurológicas geralmente precedem a detecção do câncer. O perfil de autoanticorpos no soro ou líquido cefalorraquidiano prediz o tipo de câncer [ver encefalite paraneoplásica do tronco cerebral: definição positiva de autoanticorpo neural]. As anormalidades da ressonância magnética geralmente se limitam à atrofia cerebelar e um fluido cefalorraquiano inflamatório é típico.
@@ description / en / description / en @@
+Paraneoplastic cerebellar degeneration results from a targeted attack on the brainstem as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. Patients present subacutely with symptoms and signs referable to the cerebellum. Neurological manifestations typically precede cancer detection. The autoantibody profile in the serum or cerebrospinal fluid predicts the cancer type [see paraneoplastic brainstem encephalitis: neural autoantibody positive definition]. MRI abnormalities are usually limited to cerebellar atrophy and an inflammatory spinal fluid is typical.
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+August 2026Timestamp +2026-08-13T00:00:00Z
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Latest revision as of 09:29, 15 August 2026

Paraneoplastic cerebellar degeneration results from a targeted attack on the brainstem as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. Patients present subacutely with symptoms and signs referable to the cerebellum. Neurological manifestations typically precede cancer detection. The autoantibody profile in the serum or cerebrospinal fluid predicts the cancer type [see paraneoplastic brainstem encephalitis: neural autoantibody positive definition]. MRI abnormalities are usually limited to cerebellar atrophy and an inflammatory spinal fluid is typical.

Language	Label	Description	Also known as
default for all languages	ID_1087616692
English	Paraneoplastic cerebellar degeneration	Paraneoplastic cerebellar degeneration results from a targeted attack on the brainstem as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. Patients present subacutely with symptoms and signs referable to the cerebellum. Neurological manifestations typically precede cancer detection. The autoantibody profile in the serum or cerebrospinal fluid predicts the cancer type [see paraneoplastic brainstem encephalitis: neural autoantibody positive definition]. MRI abnormalities are usually limited to cerebellar atrophy and an inflammatory spinal fluid is typical.