{"entities":{"Q84135":{"pageid":74520,"ns":120,"title":"Item:Q84135","lastrevid":455287,"modified":"2026-08-15T09:29:54Z","type":"item","id":"Q84135","labels":{"mul":{"language":"mul","value":"ID_1087616692"},"pt-br":{"language":"pt-br","value":"Degenera\u00e7\u00e3o cerebelar paraneopl\u00e1sica"},"en":{"language":"en","value":"Paraneoplastic cerebellar degeneration"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A degenera\u00e7\u00e3o cerebelar paraneopl\u00e1sica resulta de um ataque direcionado ao tronco cerebral como consequ\u00eancia de uma resposta imune tumoral potencialmente eficaz iniciada por ant\u00edgenos onco-neurais derivados de um c\u00e2ncer sist\u00eamico. Os pacientes se apresentam de forma subaguda com sintomas e sinais atribu\u00edveis ao cerebelo. As manifesta\u00e7\u00f5es neurol\u00f3gicas geralmente precedem a detec\u00e7\u00e3o do c\u00e2ncer. O perfil de autoanticorpos no soro ou l\u00edquido cefalorraquidiano prediz o tipo de c\u00e2ncer [ver encefalite paraneopl\u00e1sica do tronco cerebral: defini\u00e7\u00e3o positiva de autoanticorpo neural]. As anormalidades da resson\u00e2ncia magn\u00e9tica geralmente se limitam \u00e0 atrofia cerebelar e um fluido cefalorraquiano inflamat\u00f3rio \u00e9 t\u00edpico."},"en":{"language":"en","value":"Paraneoplastic cerebellar degeneration results from a targeted attack on the brainstem as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. Patients present subacutely with symptoms and signs referable to the cerebellum. Neurological manifestations typically precede cancer detection. The autoantibody profile in the serum or cerebrospinal fluid predicts the cancer type [see paraneoplastic brainstem encephalitis: neural autoantibody positive definition]. MRI abnormalities are usually limited to cerebellar atrophy and an inflammatory spinal fluid is typical."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"6ccbefa9674d688b34a797043102d2fb94bbb73c","datavalue":{"value":"https://id.who.int/icd/entity/1087616692","type":"string"},"datatype":"url"},"type":"statement","id":"Q84135$8C87FDAE-BF76-4D76-93AE-BE41083B7182","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"b8f7dc9409f60da942d55bfd4cc0ab418a38a510","datavalue":{"value":"CID11:ID_1087616692","type":"string"},"datatype":"string"},"type":"statement","id":"Q84135$590263F5-5C16-4CEB-AAA9-82029DBD7A6A","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"cdba3800ffaf4e9c04383701f6bff58ab497ccee","datavalue":{"value":"dki-india-ID_1087616692","type":"string"},"datatype":"string"},"type":"statement","id":"Q84135$2BC1697F-33F0-4811-9CBF-63CFD6192625","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84135$67FF337A-C801-4177-8ED9-B1F4CB64A578","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84135$2C8973E5-BF65-4AAA-8BC3-16B2AF6841B9","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84135$05109813-BC65-4226-A7D2-309F061ADD1B","rank":"normal"}]},"sitelinks":{}}}}