Inflammatory inclusion body myositis (Q41416): Difference between revisions

@@ description / pt-br / description / pt-br @@
+A miosite por corpos de inclusão (MCI) é a miopatia inflamatória idiopática mais comum após os 50 anos de idade. Apresenta-se, tipicamente, com fraqueza muscular assimétrica, insidiosa e crônica, proximal de pernas e/ou distal em braços, levando a quedas recorrentes e perda de destreza. A creatinofosfoquinase (CPK) está aumentada em até 15 vezes na MCI e a eletroneuromiografia por agulha mostra principalmente uma miopatia irritativa crônica. A histopatologia do músculo demonstra exsudatos inflamatórios no endomísio circundando e invadindo as fibras musculares não necróticas, muitas vezes acompanhados de vacúolos marginados e depósitos de proteínas. Apesar da histopatologia muscular inflamatória, é provável que a MCI tenha um componente degenerativo proeminente, suportado pela refratariedade à terapia imunossupressora.
@@ description / en / description / en @@
+Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase is up to 15 times elevated in IBM and needle electromyography mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibres often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology, it is likely that IBM has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy.
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+August 2026Timestamp +2026-08-13T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
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++2026-08-13T00:00:00Z
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 Before
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@@ Property / Collection date: 13 August 2026 / rank @@
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@@ Property / Linked ICD 10 @@
+G72.4
@@ Property / Linked ICD 10: G72.4 / rank @@
+Normal rank

Latest revision as of 07:34, 13 August 2026

Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase is up to 15 times elevated in IBM and needle electromyography mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibres often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology, it is likely that IBM has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy.

Language	Label	Description	Also known as
default for all languages	4A41.20
English	Inflammatory inclusion body myositis	Inclusion body myositis (IBM) is the most common idiopathic inflammatory myopathy after age 50. It typically presents with chronic insidious proximal leg and/or distal arm asymmetric muscle weakness leading to recurrent falls and loss of dexterity. Creatine kinase is up to 15 times elevated in IBM and needle electromyography mostly shows a chronic irritative myopathy. Muscle histopathology demonstrates endomysial inflammatory exudates surrounding and invading non-necrotic muscle fibres often times accompanied by rimmed vacuoles and protein deposits. Despite inflammatory muscle pathology, it is likely that IBM has a prominent degenerative component as supported by refractoriness to immunosuppressive therapy.