Paraneoplastic opsoclonus myoclonus (Q100589): Difference between revisions
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Opsoclônus-mioclônus (OM) paraneoplásico resulta de um ataque direcionado ao tronco esncefálico como consequência de uma resposta imune tumoral potencialmente efetiva iniciada por antígenos onco-neurais derivados de um câncer sistêmico. Em crianças o câncer quase sempre é o neuroblastoma, enquanto em adultos uma variedade de cânceres podem ser detectados, mas os cânceres de pequenas células do pulmão e de mama são os mais comuns. Em adultos, OM paraneoplásica está frequentemente associada ao autoanticorpo neural anticorpo nuclear anti-neuronal tipo 2 [ANNA-2 ou anti-Ri], mas outros autoanticorpos neurais também podem acompanhar o OM. _x000D_ Autoanticorpos associados: _x000D_ ANNA-2(anti-Ri) (autoanticorpo nuclear antineuronal tipo 2); NMDA-R (autoanticorpos contra receptor de N-metil-D-aspartato). | |||||||||||||||
| description / en | description / en | ||||||||||||||
Paraneoplastic opsoclonus myoclonus (OM) results from a targeted attack on the brainstem as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. In children the cancer is almost always neuroblastoma, while in adults a variety of cancers may be detected but small-cell lung cancers and breast cancers are most common. In adults paraneoplastic OM it is often associated with the neural autoantibody anti-neuronal nuclear antibody type 2 [ANNA-2 or anti-Ri], but other neural autoantibodies may also accompany OM. Associated autoantibodies: ANNA-2(anti-Ri) (antineuronal nuclear autoantibody type 2); NMDA-R (N-methyl-D-aspartate receptor autoantibodies). | |||||||||||||||
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| Property / Canonical URI: https://id.who.int/icd/entity/2088074552 / rank | |||||||||||||||
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CID11:ID_2088074552 | |||||||||||||||
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dki-india-ID_2088074552 | |||||||||||||||
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| Property / Knowledge Architect: https://pauloleads.com.br/cases-publicos/ / rank | |||||||||||||||
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15 August 2026
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| Property / Collection date: 15 August 2026 / rank | |||||||||||||||
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Latest revision as of 17:18, 16 August 2026
Paraneoplastic opsoclonus myoclonus (OM) results from a targeted attack on the brainstem as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. In children the cancer is almost always neuroblastoma, while in adults a variety of cancers may be detected but small-cell lung cancers and breast cancers are most common. In adults paraneoplastic OM it is often associated with the neural autoantibody anti-neuronal nuclear antibody type 2 [ANNA-2 or anti-Ri], but other neural autoantibodies may also accompany OM. Associated autoantibodies: ANNA-2(anti-Ri) (antineuronal nuclear autoantibody type 2); NMDA-R (N-methyl-D-aspartate receptor autoantibodies).
| Language | Label | Description | Also known as |
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| default for all languages | ID_2088074552 |
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| English | Paraneoplastic opsoclonus myoclonus |
Paraneoplastic opsoclonus myoclonus (OM) results from a targeted attack on the brainstem as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. In children the cancer is almost always neuroblastoma, while in adults a variety of cancers may be detected but small-cell lung cancers and breast cancers are most common. In adults paraneoplastic OM it is often associated with the neural autoantibody anti-neuronal nuclear antibody type 2 [ANNA-2 or anti-Ri], but other neural autoantibodies may also accompany OM. Associated autoantibodies: ANNA-2(anti-Ri) (antineuronal nuclear autoantibody type 2); NMDA-R (N-methyl-D-aspartate receptor autoantibodies). |
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CID11:ID_2088074552
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dki-india-ID_2088074552
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Concluído
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15 August 2026
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