{"entities":{"Q100589":{"pageid":90982,"ns":120,"title":"Item:Q100589","lastrevid":574078,"modified":"2026-08-16T17:18:56Z","type":"item","id":"Q100589","labels":{"mul":{"language":"mul","value":"ID_2088074552"},"pt-br":{"language":"pt-br","value":"Opsocl\u00f4nus-miocl\u00f4nus paraneopl\u00e1sico"},"en":{"language":"en","value":"Paraneoplastic opsoclonus myoclonus"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Opsocl\u00f4nus-miocl\u00f4nus (OM) paraneopl\u00e1sico resulta de um ataque direcionado ao tronco esncef\u00e1lico como consequ\u00eancia de uma resposta imune tumoral potencialmente efetiva iniciada por ant\u00edgenos onco-neurais derivados de um c\u00e2ncer sist\u00eamico. Em crian\u00e7as o c\u00e2ncer quase sempre \u00e9 o neuroblastoma, enquanto em adultos uma variedade de c\u00e2nceres podem ser detectados, mas os c\u00e2nceres de pequenas c\u00e9lulas do pulm\u00e3o e de mama s\u00e3o os mais comuns. Em adultos, OM paraneopl\u00e1sica est\u00e1 frequentemente associada ao autoanticorpo neural anticorpo nuclear anti-neuronal tipo 2 [ANNA-2 ou anti-Ri], mas outros autoanticorpos neurais tamb\u00e9m podem acompanhar o OM. _x000D_ Autoanticorpos associados: _x000D_ ANNA-2(anti-Ri) (autoanticorpo nuclear antineuronal tipo 2); NMDA-R (autoanticorpos contra receptor de N-metil-D-aspartato)."},"en":{"language":"en","value":"Paraneoplastic opsoclonus myoclonus (OM) results from a targeted attack on the brainstem as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. In children the cancer is almost always neuroblastoma, while in adults a variety of cancers may be detected but small-cell lung cancers and breast cancers are most common. In adults paraneoplastic OM it is often associated with the neural autoantibody anti-neuronal nuclear antibody type 2 [ANNA-2 or anti-Ri], but other neural autoantibodies may also accompany OM.  Associated autoantibodies: ANNA-2(anti-Ri) (antineuronal nuclear autoantibody type 2); NMDA-R (N-methyl-D-aspartate receptor autoantibodies)."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"42e092e36f8823ccbaadc098e8df268b17bb44d4","datavalue":{"value":"https://id.who.int/icd/entity/2088074552","type":"string"},"datatype":"url"},"type":"statement","id":"Q100589$5F3080E1-B1E1-4289-B88C-70CBB6813A46","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"e868470bc139b90b18e063fffef45150cda6dc10","datavalue":{"value":"CID11:ID_2088074552","type":"string"},"datatype":"string"},"type":"statement","id":"Q100589$2809C695-A027-4528-A15A-9864CD083C75","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"8b0a55c991ef0fc2f2d39ec4a8a365c4e3e733e2","datavalue":{"value":"dki-india-ID_2088074552","type":"string"},"datatype":"string"},"type":"statement","id":"Q100589$6B857297-19D9-41D7-B0F1-96A0F16A1BB0","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q100589$9F7D15C7-7D7E-4F34-BD22-7E3BFED301C1","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q100589$91037591-E032-4BBD-8996-CC3D6687DB35","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q100589$41FDD627-B09B-409B-9EE4-1B3342AF6415","rank":"normal"}]},"sitelinks":{}}}}