Primary systemic amyloidosis affecting skin or oral cavity (Q96378): Difference between revisions
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15 August 2026
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Latest revision as of 12:20, 16 August 2026
Primary systemic amyloid, due to abnormal secretion of immunoglobulin light chain fragments as a result of plasma cell dyscrasia or multiple myeloma, may present in the skin. The commonest findings are spontaneous petechial haemorrhages, purpura and bruising. Such haemorrhage has a predilection for skin with clinically apparent amyloid infiltration: smooth, shiny, waxy, translucent papules and plaques develop, particularly on the eyelids, the neck and in flexural areas. Macroglossia occurs in 10 per cent of cases.
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| English | Primary systemic amyloidosis affecting skin or oral cavity |
Primary systemic amyloid, due to abnormal secretion of immunoglobulin light chain fragments as a result of plasma cell dyscrasia or multiple myeloma, may present in the skin. The commonest findings are spontaneous petechial haemorrhages, purpura and bruising. Such haemorrhage has a predilection for skin with clinically apparent amyloid infiltration: smooth, shiny, waxy, translucent papules and plaques develop, particularly on the eyelids, the neck and in flexural areas. Macroglossia occurs in 10 per cent of cases. |
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CID11:ID_848611604
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dki-india-ID_848611604
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Concluído
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15 August 2026
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