Amyotrophic lateral sclerosis with frontotemporal dementia (Q86922): Difference between revisions

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Latest revision as of 12:29, 15 August 2026

Cognitive impairment and behaviour changes particularly reflecting dysfunction of frontal lobe functions, such as planning, executive functions, and performing complex sequential tasks, occur in a proportion of ALS patients. There is a continuum, ranging from mild changes to frank frontotemporal dementia (FTD). Neuroimaging may demonstrate atrophy, hypoperfusion, and hypometabolism of frontal and temporal lobes. Patients with C9ORF72 expansions may present with FTD, ALS or overlap syndromes.

Language	Label	Description	Also known as
default for all languages	ID_2134326880
English	Amyotrophic lateral sclerosis with frontotemporal dementia	Cognitive impairment and behaviour changes particularly reflecting dysfunction of frontal lobe functions, such as planning, executive functions, and performing complex sequential tasks, occur in a proportion of ALS patients. There is a continuum, ranging from mild changes to frank frontotemporal dementia (FTD). Neuroimaging may demonstrate atrophy, hypoperfusion, and hypometabolism of frontal and temporal lobes. Patients with C9ORF72 expansions may present with FTD, ALS or overlap syndromes.