Autoimmune movement disorder (Q84148): Difference between revisions

@@ description / pt-br / description / pt-br @@
+Os transtornos do movimento autoimune são distúrbios inflamatórios imunomediados do sistema nervoso central que podem responder à imunoterapia e não estão associados ao câncer. Eles podem ser pós-infecciosos (por exemplo, coreia de Sydenhams) e normalmente se apresentam com hipocinética subaguda (parkinsonismo [acinesia, bradicinesia, rigidez ou instabilidade postural]) ou distúrbios do movimento hipercinéticos (coreia, tremor [núcleos cerebelares / basais associados], distonia ou mioclonia). A ressonância magnética pode revelar anormalidades do sinal T2 nos núcleos da base e o líquido cefalorraquiano pode ser inflamatório (contagem elevada de leucócitos, proteína acentuadamente elevada ou excesso de bandas oligoclonais). Autoanticorpos específicos neurais são raramente detectados, embora autoanticorpos não específicos de órgãos (por exemplo, autoanticorpos antifosfolipídeos) ocorram com frequência._x000D_ _x000D_ Os autoanticorpos neurais associados incluem:_x000D_ _x000D_ DPPX (proteína semelhante a dipeptidil peptidase-6), GAD65 (anticorpos de descarboxilase-65 do ácido glutâmico), NMDA-R (autoanticorpos do receptor de N-metil-D-aspartato), VGKC (LGI1, CASPR2) anticorpos de canal de potássio com restrição de voltagem.
@@ description / en / description / en @@
+Autoimmune movement disorders are immune-mediated inflammatory disorders of the central nervous that may respond to immunotherapy and are not associated with cancer. They may be post-infectious (e.g. Sydenhams chorea) and typically present with sub-acute hypokinetic (parkinsonism [akinesia, bradykinesia, rigidity or postural instability]) or hyperkinetic (chorea, tremor [cerebellar/basal ganglia associated], dystonia or myoclonus) movement disorders. MRI may reveal T2-signal abnormalities in the basal ganglia and spinal fluid may be inflammatory (elevated white cell count, markedly elevated protein or excess oligoclonal bands). Neural specific autoantibodies are rarely detected although non-organ specific autoantibodies (e.g. anti-phospholipid autoantibodies) occur frequently.  Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase–like protein-6), GAD65 (glutamic acid decarboxylase-65 antibodies), NMDA-R (N-methyl-D-aspartate receptor autoantibodies),VGKC (LGI1, CASPR2) voltage gated potassium channel antibodies.
@@ Property / Canonical URI @@
+https://id.who.int/icd/entity/1557930774
@@ Property / Canonical URI: https://id.who.int/icd/entity/1557930774 / rank @@
+Normal rank
@@ Property / CURIE @@
+CID11:ID_1557930774
@@ Property / CURIE: CID11:ID_1557930774 / rank @@
+Normal rank
@@ Property / Canary Token @@
+dki-india-ID_1557930774
@@ Property / Canary Token: dki-india-ID_1557930774 / rank @@
+Normal rank
@@ Property / Verification Status @@
+Concluído
@@ Property / Verification Status: Concluído / rank @@
+Normal rank
@@ Property / Knowledge Architect @@
+https://pauloleads.com.br/cases-publicos/
+Normal rank
@@ Property / Collection date @@
+August 2026Timestamp +2026-08-13T00:00:00Z
Timezone +00:00
Calendar Gregorian
Precision 1 day
Before 0
After 0
-Timestamp
++2026-08-13T00:00:00Z
-Timezone
++00:00
-Calendar
+Gregorian
-Precision
+day
 Before
 After
@@ Property / Collection date: 13 August 2026 / rank @@
+Normal rank

Latest revision as of 09:30, 15 August 2026

Autoimmune movement disorders are immune-mediated inflammatory disorders of the central nervous that may respond to immunotherapy and are not associated with cancer. They may be post-infectious (e.g. Sydenhams chorea) and typically present with sub-acute hypokinetic (parkinsonism [akinesia, bradykinesia, rigidity or postural instability]) or hyperkinetic (chorea, tremor [cerebellar/basal ganglia associated], dystonia or myoclonus) movement disorders. MRI may reveal T2-signal abnormalities in the basal ganglia and spinal fluid may be inflammatory (elevated white cell count, markedly elevated protein or excess oligoclonal bands). Neural specific autoantibodies are rarely detected although non-organ specific autoantibodies (e.g. anti-phospholipid autoantibodies) occur frequently. Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase–like protein-6), GAD65 (glutamic acid decarboxylase-65 antibodies), NMDA-R (N-methyl-D-aspartate receptor autoantibodies),VGKC (LGI1, CASPR2) voltage gated potassium channel antibodies.

Language	Label	Description	Also known as
default for all languages	ID_1557930774
English	Autoimmune movement disorder	Autoimmune movement disorders are immune-mediated inflammatory disorders of the central nervous that may respond to immunotherapy and are not associated with cancer. They may be post-infectious (e.g. Sydenhams chorea) and typically present with sub-acute hypokinetic (parkinsonism [akinesia, bradykinesia, rigidity or postural instability]) or hyperkinetic (chorea, tremor [cerebellar/basal ganglia associated], dystonia or myoclonus) movement disorders. MRI may reveal T2-signal abnormalities in the basal ganglia and spinal fluid may be inflammatory (elevated white cell count, markedly elevated protein or excess oligoclonal bands). Neural specific autoantibodies are rarely detected although non-organ specific autoantibodies (e.g. anti-phospholipid autoantibodies) occur frequently. Associated neural autoantibodies include: DPPX (dipeptidyl-peptidase–like protein-6), GAD65 (glutamic acid decarboxylase-65 antibodies), NMDA-R (N-methyl-D-aspartate receptor autoantibodies),VGKC (LGI1, CASPR2) voltage gated potassium channel antibodies.