{"entities":{"Q94473":{"pageid":84866,"ns":120,"title":"Item:Q94473","lastrevid":529935,"modified":"2026-08-16T09:37:25Z","type":"item","id":"Q94473","labels":{"mul":{"language":"mul","value":"ID_1307765114"},"pt-br":{"language":"pt-br","value":"Doen\u00e7a de Keshan devido a defici\u00eancia de sel\u00eanio"},"en":{"language":"en","value":"Keshan disease due to selenium deficiency"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A doen\u00e7a de Keshan \u00e9 uma doen\u00e7a end\u00eamica em crian\u00e7as de 2 a 10 anos e mulheres em idade reprodutiva que vivem em \u00e1reas do Nordeste e do Sudoeste da China. As manifesta\u00e7\u00f5es t\u00edpicas s\u00e3o fadiga mesmo ap\u00f3s exerc\u00edcios leves, arritmia card\u00edaca e palpita\u00e7\u00f5es, perda de apetite, insufici\u00eancia card\u00edaca, cardiomegalia e insufici\u00eancia card\u00edaca congestiva. As altera\u00e7\u00f5es patol\u00f3gicas incluem necrose mioc\u00e1rdica multifocal e fibrose. As art\u00e9rias coron\u00e1rias essencialmente n\u00e3o s\u00e3o afetadas. A doen\u00e7a tem uma acentuada flutua\u00e7\u00e3o sazonal na incid\u00eancia e pode aparecer ap\u00f3s apenas 3 meses de exposi\u00e7\u00e3o a condi\u00e7\u00f5es em localidades conhecidas por estarem associadas a um alto risco de miocardite. Uma vez estabelecida a doen\u00e7a, o sel\u00eanio tem pouco ou nenhum valor terap\u00eautico. No entanto, a profilaxia, que consiste na administra\u00e7\u00e3o oral de sel\u00eanio 3 meses antes dos per\u00edodos de maior risco previsto, \u00e9 altamente eficaz."},"en":{"language":"en","value":"Keshan disease is an endemic condition in children aged 2\u201310 years and women of childbearing age living in areas from Northeast and Southwest China. Typical manifestations are fatigue after even mild exercise, cardiac arrhythmia and palpitations, loss of appetite, cardiac insufficiency, cardiomegaly, and congestive heart failure. Pathological changes include a multifocal myocardial necrosis and fibrosis. The coronary arteries are essentially unaffected. The disease has a marked seasonal fluctuation in incidence and may appear after only 3 months exposure to conditions in localities known to be associated with a high risk of myocarditis. Once the disease is established, selenium is of little or no therapeutic value. However, prophylaxis consisting of oral administration of selenium 3 months before the periods of highest anticipated risk is highly effective."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"51cff942687e3706be5db585c0efc6f6d4f8bfcd","datavalue":{"value":"https://id.who.int/icd/entity/1307765114","type":"string"},"datatype":"url"},"type":"statement","id":"Q94473$0E835542-32CC-45D6-8AB2-3A43C17E74D0","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"b2a975c9401a3110def9820bd8ac05d7b9c852cf","datavalue":{"value":"CID11:ID_1307765114","type":"string"},"datatype":"string"},"type":"statement","id":"Q94473$5D99960B-2C2E-4008-AED0-A4338B7A116C","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"d1131ce6ab31d79d116ec4d5a591c4ec0ccff519","datavalue":{"value":"dki-india-ID_1307765114","type":"string"},"datatype":"string"},"type":"statement","id":"Q94473$319A4294-6493-452C-9782-88F71570217D","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q94473$747709D7-2201-4478-8A8C-76F8AAA087D8","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q94473$1CE1C3E5-E0BF-4261-8B46-EFE0D74F4E39","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q94473$C986CEAE-39DA-4DE0-BB9D-C05A28580298","rank":"normal"}]},"sitelinks":{}}}}