{"entities":{"Q90737":{"pageid":81129,"ns":120,"title":"Item:Q90737","lastrevid":503336,"modified":"2026-08-15T17:43:40Z","type":"item","id":"Q90737","labels":{"mul":{"language":"mul","value":"ID_194675725"},"pt-br":{"language":"pt-br","value":"Polimiosite necrosante"},"en":{"language":"en","value":"Necrotising polymyositis"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Polimiosite necrosante \u00e9 um transtorno muscular inflamat\u00f3rio, imune caracterizado por n\u00edveis elevados de CK, fraqueza muscular moderada a grave de in\u00edcio agudo ou subagudo, e com caracter\u00edsticas histol\u00f3gicas de necrose da fibra muscular mediada por macr\u00f3fagos como principal c\u00e9lula efetora. N\u00e3o h\u00e1 infiltrados de c\u00e9lulas T ou express\u00e3o de MHC-I. No entanto, alguns pacientes t\u00eam anticorpos contra part\u00edculas de reconhecimento de sinal (SRP). A doen\u00e7a \u00e9 multifatorial: c\u00e2ncer, infec\u00e7\u00e3o viral, uso de estatinas, exposi\u00e7\u00e3o a agentes t\u00f3xicos ou processo autoimune subjacente; outros n\u00e3o t\u00eam outra doen\u00e7a ou exposi\u00e7\u00e3o aparente a agentes ex\u00f3genos."},"en":{"language":"en","value":"Necrotising polymyositis is an immune inflammatory muscle disorders characterised by high CK level, moderate to severe muscle weakness of acute or subacute onset and with histological features of muscle fibre necrosis mediated by macrophages as the main effector cell. There are no T cell infiltrates or MHC-I expression. However, some patients have antibodies against signal recognition particles (SRP). The disease is multifactorial: cancer, viral infection, use of statins, exposure to toxic agents, or underlying autoimmune process; others have no other disease or apparent exposure to exogenous agents."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"d7adaecb49f9f6135eab08ea4d41ddaab5defbff","datavalue":{"value":"https://id.who.int/icd/entity/194675725","type":"string"},"datatype":"url"},"type":"statement","id":"Q90737$0FA84749-6274-4E79-9A67-4248B7159403","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"943b2d37aa1af5675b3f3f0d4b08611012e8c358","datavalue":{"value":"CID11:ID_194675725","type":"string"},"datatype":"string"},"type":"statement","id":"Q90737$DC9EBECB-29A4-4CBA-8B37-69B5B37D2912","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"df2ac842696b4464b9211278ad9a8ca53c787dc2","datavalue":{"value":"dki-india-ID_194675725","type":"string"},"datatype":"string"},"type":"statement","id":"Q90737$EFF61C40-BE03-4A79-A95D-2FC18BE220FE","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q90737$5C4F3AB2-AD38-45CF-B9F4-8FF3F09A56C0","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q90737$414CFD79-5570-4276-B734-AC3652743BA8","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q90737$86186A20-20B6-4945-95B4-7ABEBC8ADEBC","rank":"normal"}]},"sitelinks":{}}}}