{"entities":{"Q88656":{"pageid":79041,"ns":120,"title":"Item:Q88656","lastrevid":488166,"modified":"2026-08-15T14:59:50Z","type":"item","id":"Q88656","labels":{"mul":{"language":"mul","value":"ID_1979177138"},"pt-br":{"language":"pt-br","value":"Miastenia gravis, soronegativa"},"en":{"language":"en","value":"Myasthenia gravis, seronegative"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Em aproximadamente 50% dos pacientes soronegativos para o receptor da acetilcolina com Miastenia Gravis generalizada (MG), nenhum autoanticorpo contra a quinase muscular espec\u00edfica (MuSK) ou contra AChRs p\u00f4de ser detectado por m\u00e9todos de rotina. Neste grupo, autoanticorpos contra a prote\u00edna 4 relacionada ao receptor de lipoprote\u00edna de baixa densidade (LRP4) foram identificados no soro de v\u00e1rios destes pacientes com uma varia\u00e7\u00e3o de frequ\u00eancia (7-32%). Existem tamb\u00e9m pacientes duplamente positivos (com LRP4 e AChR ou MuSK). Anticorpos anti-agrina foram detectados em combina\u00e7\u00e3o com autoanticorpos contra MuSK, LRP4 ou AChRs em 10-15% dos pacientes com MG generalizada."},"en":{"language":"en","value":"In approximately 50% of the Acetylcholine receptor-seronegative patients with generalised Myasthenia Gravis (MG), no autoantibodies against Muscle-specific kinase (MuSK) or against AChRs could be detected by routine methods. In this group autoantibodies against the low-density lipoprotein receptor-related protein 4 (LRP4) have been identified in several dSN-MG sera with a frequency variation (7-32%). There are also double positive patients (with LRP4 and AChR or MuSK). Anti-agrin antibodies were detected in combination with autoantibodies against MuSK, LRP4, or AChRs in 10-15% of the generalised MG patients."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"2068ce7973f0fe0a6232cabbc9a56382b10d70cd","datavalue":{"value":"https://id.who.int/icd/entity/1979177138","type":"string"},"datatype":"url"},"type":"statement","id":"Q88656$6434425E-749E-46FB-84BC-5609396A8C3F","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"52bc78f14c57bf1d0fa4d56b6dfe2145ed957ea8","datavalue":{"value":"CID11:ID_1979177138","type":"string"},"datatype":"string"},"type":"statement","id":"Q88656$A534321A-EA0F-49E8-B4C7-FAAD7526E6D2","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"7f226c1c23926f3669dc99011c243a4954ad42fa","datavalue":{"value":"dki-india-ID_1979177138","type":"string"},"datatype":"string"},"type":"statement","id":"Q88656$1543C3E3-DA29-432A-9565-61C560FFA629","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q88656$613F011D-CA42-47B0-B204-7A552EDB3DB5","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q88656$967253E6-C386-4B52-B17A-3F9BE56444D1","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q88656$25A90646-5FA5-4AA0-B7C1-C16EA2D5D568","rank":"normal"}]},"sitelinks":{}}}}