{"entities":{"Q86928":{"pageid":77313,"ns":120,"title":"Item:Q86928","lastrevid":475625,"modified":"2026-08-15T12:30:07Z","type":"item","id":"Q86928","labels":{"mul":{"language":"mul","value":"ID_1780993349"},"pt-br":{"language":"pt-br","value":"Complexo de esclerose lateral amiotr\u00f3fica-parkinsonismo-dem\u00eancia de Guam"},"en":{"language":"en","value":"Amyotrophic lateral sclerosis-parkinsonism-dementia complex of Guam"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Uma alta taca de preval\u00eancia de ELA e complexo de Parkinson-dem\u00eancia (PDC) foi observado no povo Chamorro de Guam. Os pacientes que apresentam doen\u00e7a com predomin\u00e2ncia motora apresentam caracter\u00edsticas consistentes com ELA cl\u00e1ssica, e uma propor\u00e7\u00e3o menor desses pacientes pode apresentar dem\u00eancia sobreposta ou parkinsonismo. Pacientes com PDC comumente demonstram manifesta\u00e7\u00f5es de disfun\u00e7\u00e3o do sistema motor, como fraqueza dos membros, fascicula\u00e7\u00f5es e hiperreflexia. Existem agrupamentos familiares de doen\u00e7as, mas os padr\u00f5es de heran\u00e7a gen\u00e9tica n\u00e3o foram definidos. Neuropatologia \u00fanica foi identificada com altera\u00e7\u00f5es cerebrais t\u00edpicas de ALS misturadas com ac\u00famulos de emaranhados neurofibrilares. A incid\u00eancia de ELA e PDC caiu recentemente."},"en":{"language":"en","value":"A high prevalence focus of ALS and Parkinsons-dementia complex (PDC) has been noted in the Chamorro people of Guam. Patients presenting with motor-predominant disease display features consistent with classical ALS, and a smaller proportion of these patients may display superimposed dementia or parkinsonism. Patients with PDC commonly demonstrate manifestations of motor system dysfunction such as limb weakness, fasciculations and hyperreflexia. There are familial groupings of disease but genetic inheritance patterns have not been defined. Unique neuropathology has been identified with brain changes typical of ALS admixed with accumulations of neurofibrillary tangles. The incidence of ALS and PDC has fallen recently."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"f39c098d7988621959d843a0be3b42a9edd7b342","datavalue":{"value":"https://id.who.int/icd/entity/1780993349","type":"string"},"datatype":"url"},"type":"statement","id":"Q86928$89F69712-DA60-4EBE-AA94-E11933BF151D","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"440e5eecbdf73352323200d093c612393d7a9318","datavalue":{"value":"CID11:ID_1780993349","type":"string"},"datatype":"string"},"type":"statement","id":"Q86928$15924A6C-BB3B-48FC-B4D0-E0A6129404FC","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"6d48daf0ae9d5dcf5394bd1ea72c5f7ea0a3a758","datavalue":{"value":"dki-india-ID_1780993349","type":"string"},"datatype":"string"},"type":"statement","id":"Q86928$DFC30DE3-CCBC-47EE-8BBC-5CF434CD296C","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q86928$555C9F8B-3B26-433F-9424-2B6C7B6C21E2","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q86928$EA2B8BB6-CD67-4AE0-B3BA-B4EF85602301","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q86928$5482BA1F-7FBB-47CB-80F3-977B11935FC4","rank":"normal"}]},"sitelinks":{}}}}