{"entities":{"Q85881":{"pageid":76266,"ns":120,"title":"Item:Q85881","lastrevid":467988,"modified":"2026-08-15T11:14:30Z","type":"item","id":"Q85881","labels":{"mul":{"language":"mul","value":"ID_1181962223"},"pt-br":{"language":"pt-br","value":"S\u00edndrome do QT longo tipo 3"},"en":{"language":"en","value":"Long QT syndrome type 3"}},"descriptions":{"pt-br":{"language":"pt-br","value":"O tipo LQT3 de s\u00edndrome do QT longo envolve a muta\u00e7\u00e3o do gene que codifica a subunidade alfa do canal de \u00edons Na+. Este gene est\u00e1 localizado no cromossomo 3p21-24 e \u00e9 conhecido como SCN5A (tamb\u00e9m hH1 e NaV1.5). As muta\u00e7\u00f5es envolvidas no QTL3 retardam a inativa\u00e7\u00e3o do canal de Na+, resultando no prolongamento do influxo de Na+ durante a despolariza\u00e7\u00e3o. No entanto, os canais de s\u00f3dio mutantes ficam inativos mais rapidamente e podem abrir repetidamente durante o potencial de a\u00e7\u00e3o."},"en":{"language":"en","value":"The LQT3 type of long QT syndrome involves mutation of the gene that encodes the alpha subunit of the Na+ ion channel. This gene is located on chromosome 3p21-24, and is known as SCN5A (also hH1 and NaV1.5). The mutations involved in LQT3 slow the inactivation of the Na+ channel, resulting in prolongation of the Na+ influx during depolarization. However, the mutant sodium channels inactivate more quickly, and may open repetitively during the action potential."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"24b84daef1f495db0ffbe68339964badb3172356","datavalue":{"value":"https://id.who.int/icd/entity/1181962223","type":"string"},"datatype":"url"},"type":"statement","id":"Q85881$E58E4D10-1814-4D3C-B165-05171A5A4718","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"a8c107f72626391e4e52d59a030c744465cfbffa","datavalue":{"value":"CID11:ID_1181962223","type":"string"},"datatype":"string"},"type":"statement","id":"Q85881$0EC5DDF9-65D3-4786-B450-8BF7D880CC2D","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"291c3ef17af4dadb14eb1502fef9ac10f0af4c58","datavalue":{"value":"dki-india-ID_1181962223","type":"string"},"datatype":"string"},"type":"statement","id":"Q85881$59522000-B18C-49D1-A274-3876140ADF2B","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q85881$AE052780-AA3F-49AA-B001-B86517DD4E52","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q85881$1C1ABC9F-0BC2-446D-A897-5D11F93C76C4","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q85881$CFFE528C-6A58-4716-8C73-BEF5F73DBE19","rank":"normal"}]},"sitelinks":{}}}}