{"entities":{"Q85875":{"pageid":76260,"ns":120,"title":"Item:Q85875","lastrevid":467943,"modified":"2026-08-15T11:14:09Z","type":"item","id":"Q85875","labels":{"mul":{"language":"mul","value":"ID_2041488028"},"pt-br":{"language":"pt-br","value":"S\u00edndrome do QT longo tipo 2"},"en":{"language":"en","value":"Long QT syndrome type 2"}},"descriptions":{"pt-br":{"language":"pt-br","value":"O tipo LQT2 \u00e9 a segunda localiza\u00e7\u00e3o gen\u00e9tica qu\u00e9 \u00e9 mais comumente afetada na s\u00edndrome do QT longo, representando cerca de 25 a 30 por cento de todos os casos. Esta forma de s\u00edndrome do QT longo muito provavelmente envolve muta\u00e7\u00f5es do gene humano relacionado ao \u00e9ter a-go-go (hERG) no cromossomo 7. O gene hERG (tamb\u00e9m conhecido como KCNH2) \u00e9 parte do componente r\u00e1pido da corrente retificadora de pot\u00e1ssio (IKr). (A corrente IKr \u00e9 principalmente respons\u00e1vel pelo t\u00e9rmino do potencial de a\u00e7\u00e3o card\u00edaco e, portanto, pela dura\u00e7\u00e3o do intervalo QT). O gene hERG de funcionamento normal permite prote\u00e7\u00e3o contra p\u00f3s-despolariza\u00e7\u00f5es precoces (PDP)."},"en":{"language":"en","value":"The LQT2 type is the second most common gene location that is affected in long QT syndrome, making up about 25 to 30 percent of all cases. This form of long QT syndrome most likely involves mutations of the human ether-a-go-go related gene (hERG) on chromosome 7. The hERG gene (also known as KCNH2) is part of the rapid component of the potassium rectifying current (IKr). (The IKr current is mainly responsible for the termination of the cardiac action potential, and therefore the length of the QT interval.) The normally functioning hERG gene allows protection against early after depolarizations (EADs)."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"e18860c50812ea381f67eb969882cd1e7b6206ec","datavalue":{"value":"https://id.who.int/icd/entity/2041488028","type":"string"},"datatype":"url"},"type":"statement","id":"Q85875$B9D57BC4-E7EC-4F5E-8EBB-E7F184A8917D","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"3522fccabbca0cd64b962e4fb11dee9dae7380d2","datavalue":{"value":"CID11:ID_2041488028","type":"string"},"datatype":"string"},"type":"statement","id":"Q85875$64346DEB-592B-4410-89BD-00196B3D63E5","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"04fde6e7a9f510b9c28af84e2c9f95312b831f39","datavalue":{"value":"dki-india-ID_2041488028","type":"string"},"datatype":"string"},"type":"statement","id":"Q85875$3C74D846-BC1C-40C0-BE38-FE463E2CFF08","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q85875$1AC8EA5B-555D-414E-9230-F9E0177987AE","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q85875$4A1CE558-1A9B-4606-BEF9-4AB2CA57285F","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q85875$577FB59C-3C3D-467E-8BD4-21AED333345B","rank":"normal"}]},"sitelinks":{}}}}