{"entities":{"Q85311":{"pageid":75696,"ns":120,"title":"Item:Q85311","lastrevid":463841,"modified":"2026-08-15T10:40:36Z","type":"item","id":"Q85311","labels":{"mul":{"language":"mul","value":"ID_96616786"},"pt-br":{"language":"pt-br","value":"Hemofilia A grave"},"en":{"language":"en","value":"Severe haemophilia A"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Hemofilia A grave \u00e9 uma forma de hemofilia A (veja este termo) caracterizada por uma defici\u00eancia importante de fator VIII, levando a hemorragias espont\u00e2neas frequentes e a sangramento anormal como resultado de ferimentos menores, ou subsequente a cirurgias ou extra\u00e7\u00f5es dent\u00e1rias. Hemofilia A grave responde por cerca de 40% de todos os casos de hemofilia A. A atividade biol\u00f3gica do fator VIII \u00e9 inferior a 1%. A tranmiss\u00e3o \u00e9 recessiva ligada ao X, e o transtorno \u00e9 causado por muta\u00e7\u00f5es no gene F8 (Xq28), que codifica o fator VIII da coagula\u00e7\u00e3o."},"en":{"language":"en","value":"Severe haemophilia A is a form of haemophilia A (see this term) characterised by a large deficiency of factor VIII leading to frequent spontaneous haemorrhage and abnormal bleeding as a result of minor injuries, or following surgery or tooth extraction. Severe haemophilia A accounts for around 40% of all cases of haemophilia A. The biological activity of factor VIII is below 1%. Transmission is X-linked recessive and the disorder is caused by mutations in the F8 gene (Xq28) encoding coagulation factor VIII."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"15a02a60aeabe2db6ffe853f974353adc2c54b98","datavalue":{"value":"https://id.who.int/icd/entity/96616786","type":"string"},"datatype":"url"},"type":"statement","id":"Q85311$27AF22D8-D88D-46EC-9E59-B43F76ABBAE3","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"e3aad32488ae491ca81ede4707d866dd7e2a5d46","datavalue":{"value":"CID11:ID_96616786","type":"string"},"datatype":"string"},"type":"statement","id":"Q85311$E9928AEB-3132-494F-9A64-54E226B7D651","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"f588e932b326579f4383b5a8c3443e3398454282","datavalue":{"value":"dki-india-ID_96616786","type":"string"},"datatype":"string"},"type":"statement","id":"Q85311$CC4C83FA-75DF-4013-AE48-3112591DC053","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q85311$E2DA0DE0-350A-4EB1-9005-CE7FAA3ECFAF","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q85311$599B7950-D37A-4942-A613-067CA9DCFA33","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q85311$6A625B24-63A6-44BA-A957-D71B852552D4","rank":"normal"}]},"sitelinks":{}}}}