{"entities":{"Q84157":{"pageid":74542,"ns":120,"title":"Item:Q84157","lastrevid":455457,"modified":"2026-08-15T09:31:18Z","type":"item","id":"Q84157","labels":{"mul":{"language":"mul","value":"ID_771780430"},"pt-br":{"language":"pt-br","value":"S\u00edndrome da pessoa r\u00edgida"},"en":{"language":"en","value":"Stiff person syndrome"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A s\u00edndrome da pessoa r\u00edgida (SPR) \u00e9 uma doen\u00e7a neurol\u00f3gica autoimune rara caracterizada por espasmos musculares proximais / axiais dolorosos desencadeados com rigidez que levam a incapacidade progressiva e deformidades da coluna vertebral (por exemplo, lordose lombar exagerada). H\u00e1 uma predomin\u00e2ncia do sexo feminino e o diabetes tipo 1 geralmente coexiste. A eletrofisiologia revela hiperexcitabilidade dos neur\u00f4nios motores espinais. \u00c9 frequentemente acompanhado por autoanticorpos GAD-65 em t\u00edtulos elevados, mas outros autoanticorpos neurais foram relatados (por exemplo, anticorpos do receptor de glicina). A SPR pode ser paraneopl\u00e1sica (classicamente associado ao c\u00e2ncer de mama e anfifisina IgG).A SPR \u00e9 subdividida em formas cl\u00e1ssicas (crit\u00e9rios diagn\u00f3sticos de Dalkas) e variantes (membro r\u00edgido isolado e encefalomielite progressiva com rigidez e mioclonia)."},"en":{"language":"en","value":"Stiff person syndrome (SPS) is a rare autoimmune neurological disorder characterised by triggered painful proximal/axial muscle spasms with rigidity which lead to progressive disability and spinal deformities (e.g. exaggerated lumbar lordosis). There is a female predominance and type-1 diabetes usually co-exists. Electrophysiology reveals hyperexcitability of spinal motor neurons. It is frequently accompanied by GAD-65 autoantibodies at high titre but other neural autoantibodies have been reported (e.g. glycine-receptor antibodies). SPS may be paraneoplastic (classically associated with breast cancer and amphiphysin IgG). SPS is subdivided into classic (Dalkas diagnostic criteria) and variant (isolated stiff limb and progressive encephalomyelitis rigidity and myoclonus) forms."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"ffe8629deee193af810a5ca38efa9a7e349604c3","datavalue":{"value":"https://id.who.int/icd/entity/771780430","type":"string"},"datatype":"url"},"type":"statement","id":"Q84157$038171AE-1DF4-4FF4-BB8C-F5ED4A2D71D7","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"982f1edaafcb31cc76e4417c348ac4b895af8d05","datavalue":{"value":"CID11:ID_771780430","type":"string"},"datatype":"string"},"type":"statement","id":"Q84157$1A1F4EE8-C851-4C30-A6F2-2C81A306090C","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"de721a7e6a3614a9de02b505e2068df5f8e8e8b0","datavalue":{"value":"dki-india-ID_771780430","type":"string"},"datatype":"string"},"type":"statement","id":"Q84157$2DACEBF2-A680-4711-A7F3-86AA42DEF870","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84157$029D6440-DC48-4F1C-A4E3-A759E2370C07","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84157$9B841C80-5296-46A3-A13C-35DE8CB38B79","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84157$D06F60BC-5604-47FF-B7BD-93D82D0A0C78","rank":"normal"}]},"sitelinks":{}}}}