{"entities":{"Q84151":{"pageid":74536,"ns":120,"title":"Item:Q84151","lastrevid":455411,"modified":"2026-08-15T09:30:56Z","type":"item","id":"Q84151","labels":{"mul":{"language":"mul","value":"ID_913443626"},"pt-br":{"language":"pt-br","value":"Inflama\u00e7\u00e3o linfoc\u00edtica cr\u00f4nica com realce perivascular pontino responsiva a esteroides"},"en":{"language":"en","value":"Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A inflama\u00e7\u00e3o linfoc\u00edtica cr\u00f4nica com realce perivascular pontino responsiva a ester\u00f3ides (CLIPPERS) \u00e9 caracterizada por uma s\u00edndrome do tronco cerebral pontina central subaguda, incluindo ataxia, disartria, diplopia e dorm\u00eancia facial com uma caracter\u00edstica de resson\u00e2ncia magn\u00e9tica marcante de realce pontilhado de gadol\u00ednio pontino central subagudo \"em sal e pimenta\" envolvendo a ponte ( \u00e0s vezes estendendo-se para envolver estruturas adjacentes) e que, por defini\u00e7\u00e3o, responde ao tratamento com corticosteroides. Investiga\u00e7\u00f5es extensas s\u00e3o necess\u00e1rias para excluir etiologias alternativas. Embora a bi\u00f3psia do tronco encef\u00e1lico / cerebelar seja \u00fatil e tipicamente revele um infiltrado de c\u00e9lulas T perivascular, predominantemente CD3-positivo, ela n\u00e3o \u00e9 necess\u00e1ria para o diagn\u00f3stico."},"en":{"language":"en","value":"Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is characterised by a subacute pontine-centric brainstem syndrome including ataxia, dysarthria, diplopia, and facial numbness with a hallmark MRI feature of punctate curvilinear patchy gadolinium enhancement \u201cpeppering\u201d the pons (sometimes extending to involve adjacent structures) and which by definition responds to corticosteroid treatment. Extensive investigations are necessary to exclude alternative etiologies. Although brainstem/cerebellar biopsy is helpful and typically reveals a perivascular, predominantly CD3-positive T cell infiltrate it is not necessary for the diagnosis."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"5c180ee21676a45ea438f277f244f585c067f2a0","datavalue":{"value":"https://id.who.int/icd/entity/913443626","type":"string"},"datatype":"url"},"type":"statement","id":"Q84151$560A9D9E-55F0-4FCE-BB8C-91F9E7E10E20","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"6a35783ac52e912be32d3bad4d8a4ad2ffdfa2ab","datavalue":{"value":"CID11:ID_913443626","type":"string"},"datatype":"string"},"type":"statement","id":"Q84151$2107025B-0B60-4966-BF8F-E36C0A1BE9C6","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"619604ea8846cf68673fc2565f8bce449cd6592a","datavalue":{"value":"dki-india-ID_913443626","type":"string"},"datatype":"string"},"type":"statement","id":"Q84151$4B6F53C8-0E2D-482C-89AF-4A4A11B772A5","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84151$8010AD67-D417-4703-BFFA-EFE97B330BE2","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84151$25492272-2086-4A48-9152-046C08617096","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84151$88C62044-797C-4EED-AB32-BD42ADFC9F42","rank":"normal"}]},"sitelinks":{}}}}