{"entities":{"Q84140":{"pageid":74525,"ns":120,"title":"Item:Q84140","lastrevid":455327,"modified":"2026-08-15T09:30:16Z","type":"item","id":"Q84140","labels":{"mul":{"language":"mul","value":"ID_1123629823"},"pt-br":{"language":"pt-br","value":"Mielopatia paraneopl\u00e1sica"},"en":{"language":"en","value":"Paraneoplastic myelopathy"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A mielopatia paraneopl\u00e1sica resulta de um ataque direcionado ao sistema nervoso central como consequ\u00eancia de uma resposta imune tumoral potencialmente eficaz iniciada por ant\u00edgenos onco-neurais derivados de um c\u00e2ncer sist\u00eamico. A mielopatia pode ocorrer isoladamente ou como um componente de uma doen\u00e7a neurol\u00f3gica multifocal. Os pacientes geralmente apresentam mielopatia progressiva subaguda antes da detec\u00e7\u00e3o do c\u00e2ncer. As anormalidades de resson\u00e2ncia magn\u00e9tica espec\u00edficas do trato s\u00e3o caracter\u00edsticas, mas nem sempre est\u00e3o presentes. O l\u00edquido cefalorraquianigeralmente \u00e9 inflamat\u00f3rio. O perfil de autoanticorpos no soro ou l\u00edquido cefalorraquidiano prediz o tipo de c\u00e2ncer (consulte Mielopatia paraneopl\u00e1sica: defini\u00e7\u00e3o positiva de autoanticorpo neural)._x000D_ _x000D_ Os autoanticorpos neurais associados incluem:_x000D_ _x000D_ Anfifisina; ANNA-1 (anti-Hu) (auto-anticorpo nuclear antineuronal tipo 1); ANNA-2 (anti-Ri) (autoanticorpo nuclear antineuronal tipo 2); AQP4-IgG (autoanticorpos aquaporina-4); CRMP5 (anti-CV2) (prote\u00edna 5 do mediador da resposta da colapsina); Ma-1; Ma-2; PCA-1 (anti-Yo) (anticorpos, autoanticorpo citoplasm\u00e1tico de c\u00e9lulas purkinje tipo 1); PCA-2 (anticorpos, autoanticorpo citoplasm\u00e1tico de c\u00e9lulas de purkinje tipo 2);"},"en":{"language":"en","value":"Paraneoplastic myelopathy results from a targeted attack on the central nervous system as a consequence of a potentially effective tumour immune response initiated by onco-neural antigens derived from a systemic cancer. The myelopathy may occur in isolation or as a component of a multifocal neurological disease. Patients typically present with a subacute progressive myelopathy prior to cancer detection. Tract-specific MRI abnormalities are characteristic but not always present. Spinal fluid is usually inflammatory. The autoantibody profile in the serum or cerebrospinal fluid predicts the cancer type (see Paraneoplastic myelopathy: neural autoantibody positive definition).  Associated neural autoantibodies include: Amphiphysin; ANNA-1(anti-Hu) (antineuronal nuclear autoantibody type 1); ANNA-2(anti-Ri) (antineuronal nuclear autoantibody type 2); AQP4-IgG (aquaporin-4 autoantibodies); CRMP5(anti-CV2) (collapsin response mediator protein 5); Ma-1; Ma-2; PCA-1(anti-Yo) (antibodies, purkinje cell cytoplasmic autoantibody type 1); PCA-2 (antibodies, purkinje cell cytoplasmic autoantibody type 2);"}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"3d2691bc42dcbf6cfe97466822c1d3e8d7db411e","datavalue":{"value":"https://id.who.int/icd/entity/1123629823","type":"string"},"datatype":"url"},"type":"statement","id":"Q84140$623E6BC2-CB61-4872-980F-B402814C2DAD","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"91bfb4b684da4ca9ef1f59dedceeefe772523db1","datavalue":{"value":"CID11:ID_1123629823","type":"string"},"datatype":"string"},"type":"statement","id":"Q84140$92414DFA-CEBF-4FDF-8736-6E4EB04F57A2","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"f76272b6a464c9a9bd20cb80a8676e3f6c8f12c2","datavalue":{"value":"dki-india-ID_1123629823","type":"string"},"datatype":"string"},"type":"statement","id":"Q84140$B8829030-DAD6-453A-90CE-E2A9F198DC77","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84140$E1CA0994-7481-48D9-A1FB-0C63905F15FF","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84140$0FC85369-2F7E-4FEE-B4EA-374D8CA6E600","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84140$C0AE8F0D-6681-44D5-A4DA-9B91D7DA4C7C","rank":"normal"}]},"sitelinks":{}}}}